Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden.
J Psychiatry Neurosci. 2012 Feb;37(2):122-8. doi: 10.1503/jpn.110024.
The receptor for advanced glycation end products (RAGE) is the main receptor for S100B, an astrogial proinflammatory mediator that has been suggested to be involved in the pathophysiology of schizophrenia. To further elucidate the possible relevance of inflammation for mental functions, we investigated a functional polymorphism in the gene coding for RAGE in relation to personality traits and susceptibility to schizophrenia.
We studied the Gly82Ser polymorphism (rs2070600, 244G>A) in 2 population-based cohorts of middle-aged participants assessed using the Karolinska Scales of Personality. In addition, we compared genotype frequencies between patients with schizophrenia and controls.
The population-based cohorts included 270 women and 247 men, and the case-control study involved 138 patients with schizophrenia and 258 controls. In the population-based cohorts, 82Ser carriers were found to have significantly higher scores for the psychoticism personality trait comprising the detachment and suspicion subscales. The case-control study revealed that the 82Ser allele was significantly more frequent among patients than controls.
This study was limited by the modest sample size and the use of a self-report measure to assess personality traits.
Our findings suggest that the proven relation between certain personality traits and schizophrenia can at least to some extent be explained on a genetic level. Also, the activated S100B-RAGE axis may be an underlying cause, not only a consequence, of the disease.
晚期糖基化终产物受体（RAGE）是 S100B 的主要受体，S100B 是一种星形胶质细胞促炎介质，它被认为与精神分裂症的病理生理学有关。为了进一步阐明炎症对精神功能的可能相关性，我们研究了编码 RAGE 的基因中的一个功能多态性与人格特质和精神分裂症易感性的关系。
我们研究了 2 个基于人群的中年参与者队列中的 Gly82Ser 多态性（rs2070600，244G>A），这些参与者使用了卡罗林斯卡人格量表进行评估。此外，我们比较了精神分裂症患者和对照组之间的基因型频率。
基于人群的队列包括 270 名女性和 247 名男性，病例对照研究包括 138 名精神分裂症患者和 258 名对照。在基于人群的队列中，发现 82Ser 携带者的精神病特质，包括分离和怀疑子量表的评分明显较高。病例对照研究显示，82Ser 等位基因在患者中明显比对照组更为常见。
这项研究受到样本量小和使用自我报告测量来评估人格特质的限制。
我们的发现表明，某些人格特质与精神分裂症之间的已知关系至少在一定程度上可以从遗传水平上解释。此外，激活的 S100B-RAGE 轴可能不仅是疾病的后果，也是疾病的潜在原因。
