氢气对手术诱导的脑损伤具有神经保护作用。
Hydrogen is neuroprotective against surgically induced brain injury.
作者信息
Eckermann Jan M, Chen Wanqiu, Jadhav Vikram, Hsu Frank Pk, Colohan Austin Rt, Tang Jiping, Zhang John H
机构信息
Department of Neurosurgery, Loma Linda University Medical Center, 11234 Anderson Street, Loma Linda, CA 92354, USA.
出版信息
Med Gas Res. 2011 May 18;1(1):7. doi: 10.1186/2045-9912-1-7.
BACKGROUND
Neurosurgical operations cause unavoidable damage to healthy brain tissues. Direct surgical injury as well as surgically induced oxidative stress contributes to the subsequent formation of brain edema. Therefore, we tested the neuroprotective effects of hydrogen (H2) in an established surgical brain injury (SBI) model in rats.
MATERIALS AND METHODS
Adult male Sprague - Dawley rats (weight 300-350g) were divided into three groups to serve as sham operated, SBI without treatment, and SBI treated with H2 (2.9%). Brain water content, myeloperoxidase (MPO) assay, lipid peroxidation (LPO), and neurological function were measured at 24 hrs after SBI.
RESULTS
SBI resulted in localized brain edema (p = < 0.001). Hydrogen (2.9%) administered concurrently with surgery significantly decreased the formation of cerebral edema (p = 0.028) and improved neurobehavioral score (p = 0.022). However, hydrogen treatment failed to reduce oxidative stress (LPO assay) or inflammation (MPO assay) in brain tissues.
CONCLUSIONS
Hydrogen appears to be promising as an effective, yet inexpensive way to reduce cerebral edema caused by surgical procedures. Hydrogen has the potential to improve clinical outcome, decrease hospital stay, and reduce overall cost to patients and the health care system.
背景
神经外科手术会对健康脑组织造成不可避免的损伤。直接手术损伤以及手术诱导的氧化应激会导致随后脑水肿的形成。因此，我们在已建立的大鼠手术性脑损伤（SBI）模型中测试了氢气（H2）的神经保护作用。
材料与方法
成年雄性Sprague-Dawley大鼠（体重300-350g）分为三组，分别作为假手术组、未治疗的SBI组和用2.9%氢气治疗的SBI组。在SBI后24小时测量脑含水量、髓过氧化物酶（MPO）测定、脂质过氧化（LPO）和神经功能。
结果
SBI导致局部脑水肿（p = < 0.001）。手术时同时给予2.9%氢气可显著减少脑水肿的形成（p = 0.028）并改善神经行为评分（p = 0.022）。然而，氢气治疗未能降低脑组织中的氧化应激（LPO测定）或炎症（MPO测定）。
结论
氢气似乎有望成为一种有效且廉价的减少手术所致脑水肿的方法。氢气有可能改善临床结局、缩短住院时间并降低患者和医疗保健系统的总体成本。
Zotero 插件