Javorac Dejan, Stajer Valdemar, Ostojic Sergej M
Faculty of Sport and Physical Education, University of Novi Sad, Novi Sad, 21000, Serbia.
Faculty of Health Sciences, University of Pecs, Pecs, H-7621, Hungary.
F1000Res. 2019 Jul 9;8:1024. doi: 10.12688/f1000research.19739.1. eCollection 2019.
Sport-related mild traumatic brain injury (TBI) is a serious trauma that could impair brain function of an injured athlete. Treatment solutions for mild TBI typically concentrate on complete rest, while non-traditional therapeutic options remain largely ineffective. Molecular hydrogen (H ) is an innovative neuroprotective agent that can easily reach the brain, yet no data are available concerning its value as a first-aid intervention after a mild TBI. This case report demonstrates the efficacy and safety of a hydrogen-producing dissolving tablet administered buccally during the first 24 hours post-injury in a professional soccer player who suffered a mild TBI. The patient received a formulated dosage of hydrogen every 2 hours, with the first intervention given immediately after an initial examination (~ 15 min after the injury). The overall score for Sport Concussion Assessment Tool 2 (SCAT2), a standardized method of evaluating injured athletes for concussion, increased from 68 points (severe disruption) at baseline to 84 points (mild disruption) at 24-h follow-up. The patient reported no side effects of hydrogen intervention. This case has demonstrated that intensive consecutive therapy with oral transmucosal hydrogen formulation is a beneficial strategy with regard to the reduction of presence and severity of symptoms of sport-related mild TBI.
与运动相关的轻度创伤性脑损伤（TBI）是一种严重创伤，可能损害受伤运动员的脑功能。轻度TBI的治疗方案通常集中于完全休息，而非传统治疗选择大多无效。分子氢（H₂）是一种创新的神经保护剂，能够轻松到达脑部，但关于其作为轻度TBI后急救干预措施的价值尚无数据。本病例报告展示了一名职业足球运动员在轻度TBI损伤后24小时内口腔含服产氢溶解片的有效性和安全性。患者每2小时接受规定剂量的氢气，首次干预在初步检查后立即进行（受伤后约15分钟）。用于评估受伤运动员脑震荡的标准化方法——运动脑震荡评估工具2（SCAT2）的总分，从基线时的68分（严重紊乱）提高到24小时随访时的84分（轻度紊乱）。患者报告氢气干预无副作用。本病例表明，口服经粘膜氢制剂的密集连续治疗是减轻与运动相关轻度TBI症状的存在和严重程度的有益策略。
