Department of Periodontology, Dental School, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Braz Oral Res. 2011 Nov-Dec;25(6):544-9. doi: 10.1590/s1806-83242011000600012.
Leukemia has been associated with oral manifestations. However, the available literature on this topic consists of mostly reports of cases, without data about the periodontal parameters that may be under the influence of hematologic factors. The aim of this cross-sectional study was to assess the correlation between the Gingival Index and Bleeding on Probing with the platelet count in patients with leukemia. Patients with diagnosis of any kind of leukemia, at any stage of treatment, having a minimum age of 14 years, treated at the Department of Hematology-Oncology of the University Hospital of Santa Maria, Brazil, between December 2009 and March 2010, were assessed. Excluded patients were: edentulous, with orthodontic appliances, with psychomotor disturbances, requiring antibiotic prophylaxis for the examinations, or those using medications associated with gingival swelling. Two trained and calibrated examiners evaluated the Plaque Index, Gingival Index (GI), Probing depth, Bleeding on Probing (BOP), and Clinical Attachment Loss. Hematologic data were collected from a blood test performed on the same day as the periodontal examination. Thirty-seven patients (26 males), aged between 15 and 80 years (mean age 41.7 ± 18.31) were evaluated. Correlation between platelet count and BOP (p > 0.05), or between platelet count and GI (p > 0.05), were both weak (Pearson's correlation coefficient r = 0.171 and r = -0.003, respectively) and not statistically significant. It can be concluded from the preliminary results that the low platelet count was not correlated with the higher prevalence of gingival and periodontal bleeding in patients with leukemia.
白血病与口腔表现有关。然而，关于这个主题的现有文献大多是病例报告，没有关于牙周参数的数据，这些参数可能受血液因素的影响。本横断面研究的目的是评估白血病患者的牙龈指数和探诊出血与血小板计数之间的相关性。评估了 2009 年 12 月至 2010 年 3 月在巴西圣玛丽亚大学医院血液肿瘤科接受任何类型白血病治疗、处于任何治疗阶段、年龄至少 14 岁的患者。排除标准为：无牙、佩戴正畸器械、精神运动障碍、需要抗生素预防检查或使用与牙龈肿胀相关药物的患者。两名经过培训和校准的检查者评估了菌斑指数、牙龈指数（GI）、探诊深度、探诊出血（BOP）和临床附着丧失。血液学数据是从同一天进行的牙周检查的血液检查中收集的。共评估了 37 名患者（26 名男性），年龄在 15 至 80 岁之间（平均年龄 41.7 ± 18.31 岁）。血小板计数与 BOP（p > 0.05）或血小板计数与 GI（p > 0.05）之间的相关性均较弱（Pearson 相关系数 r = 0.171 和 r = -0.003），且无统计学意义。根据初步结果可以得出结论，血小板计数低与白血病患者牙龈和牙周出血的高发生率无关。
