Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
J Clin Periodontol. 2012 Nov;39(11):1003-10. doi: 10.1111/j.1600-051X.2012.01936.x. Epub 2012 Aug 21.
This cross-sectional study evaluated periodontal status in patients with leukaemia and its correlation with haematological parameters.
Patients with different types of leukaemia and minimum age of 14 years were eligible. Calibrated examiners assessed Seymour index (SI), plaque index (PlI), gingival index (GI), probing depth (PD), bleeding on probing (BOP) and clinical attachment loss (CAL) and performed an interview. Haematological parameters were obtained from haemogram performed on the same day of the periodontal examinations.
Sixty-eight patients were evaluated, which corresponded to an 85% response rate. Periodontal parameters were in agreement with plaque accumulation (PlI 1.28 ± 0.5, GI 0.74 ± 0.4, PD 2.27 ± 0.6, BOP 33%, CAL 2.31 ± 1.6). PlI and CAL were statistically lower in acute leukaemia (1.13 ± 0.61 and 1.96 ± 1.7) in comparison with chronic leukaemia (1.46 ± 0.44 and 2.74 ± 1.4). Moreover, older age (95% confidence interval [CI]: 0.27-1.56), higher educational level (CI: -1.94 to -0.64) and smoker (CI: 0.39-1.96) were associated with CAL. Correlation between periodontal and haematological parameters was not observed. Correlations between GI x SI and PD x SI were statistically significant (r(S) = 0.390, p = 0.001; r(S) = 0.517, p = 0.000 respectively).
Periodontal parameters were consistent with plaque accumulation and did not correlate with haematological parameters irrespective of the leukaemia type.
本横断面研究评估了白血病患者的牙周状况及其与血液学参数的相关性。
纳入了不同类型白血病且年龄至少 14 岁的患者。经过校准的检查者评估了 Seymour 指数（SI）、菌斑指数（PlI）、牙龈指数（GI）、探诊深度（PD）、探诊出血（BOP）和临床附着丧失（CAL），并进行了访谈。血液学参数从同日进行的全血细胞计数中获得。
共评估了 68 例患者，应答率为 85%。牙周参数与菌斑堆积情况一致（PlI 1.28 ± 0.5、GI 0.74 ± 0.4、PD 2.27 ± 0.6、BOP 33%、CAL 2.31 ± 1.6）。与慢性白血病（1.46 ± 0.44 和 2.74 ± 1.4）相比，急性白血病（1.13 ± 0.61 和 1.96 ± 1.7）的 PlI 和 CAL 统计上更低。此外，年龄较大（95%置信区间[CI]：0.27-1.56）、教育程度较高（CI：-1.94 至-0.64）和吸烟者（CI：0.39-1.96）与 CAL 相关。牙周和血液学参数之间未观察到相关性。GI x SI 和 PD x SI 之间的相关性具有统计学意义（r(S) = 0.390，p = 0.001；r(S) = 0.517，p = 0.000）。
无论白血病类型如何，牙周参数与菌斑堆积一致，与血液学参数无关。
