早期慢性淋巴细胞白血病患者牙周参数的评估
Evaluation of Periodontal Parameters in Patients with Early Stage Chronic Lymphocytic Leukemia.
作者信息
Rinčić Nives, Božić Darko, Rinčić Goran, Gaćina Petar, Plančak Darije
机构信息
Department of Dental and Oral Pathology with Periodontology, Dental Policlinic Zagreb, Perkovčeva 3, 10000 Zagreb.
Department of Periodontology, School of Dental Medicine, University of Zagreb, Gundulićeva 5, 10000 Zagreb.
出版信息
Acta Stomatol Croat. 2016 Mar;50(1):23-33. doi: 10.15644/asc50/1/4.
OBJECTIVE
To assess periodontal conditions in patients with early stage CLL and to compare it with the periodontal status of age matched healthy controls and to analyze the relationship between periodontal and hematological parameters in CLL patients.
MATERIALS AND METHODS
60 subjects were examined: 30 patients with CLL Rai 0 (test group) and 30 age-matching healthy individuals (control group). The exclusion criteria were: presence of other systemic disease or condition (e.g. diabetes), history of treatment for periodontitis, use of antibiotics during the last 3 months, use of medications. Socio-demographic data were obtained by means of a questionnaire. Participants with at least 8 teeth underwent a full mouth examination assessing API, PBI, PPD, REC and CAL. Medical data for CLL patients were collected from the patients' records, while hematological data were obtained from the hemogram.
RESULTS
Difference between groups was statistically significant for age, number of teeth and frequency of dental checkups (p<0.05). Patients with CLL had significantly higher average values of periodontal indices (API 0.81±0.18; PBI 2.72±0.68; PPD 3.40±0.53; REC 1.95±0.87, CAL 4.37±0.80) compared to the control group (API 0.69±0.15; PBI 1.91±0.45; PPD 2.51±0.40; REC 0.99±0.54; CAL 3.00±0.58). The correlation coefficients between age and periodontal indices showed statistically significance between age and REC (r=0.357; p<0.01), and age and CAL (r=0.295; p<0.05). Age was not statistically significant covariate for CAL (F=2.205; p>0.05), only for REC (F=4.601; p<0.05). After the removal of the statistical effect of age, the difference in REC between CLL and control group remained statistically significant (F=19.732; p<0.01; eta(2)=0.287). Statistically significant association between periodontal and hematological parameters in CLL patients was not found (p>0.05).
CONCLUSION
The results of this study showed that patients with CLL had worse periodontal status compared to healthy subjects. Causal relationship between periodontal and hematological parameters was not proved.
目的
评估早期慢性淋巴细胞白血病（CLL）患者的牙周状况，并与年龄匹配的健康对照者的牙周状况进行比较，分析CLL患者牙周参数与血液学参数之间的关系。
材料与方法
检查60名受试者：30例CLL Rai 0期患者（试验组）和30名年龄匹配的健康个体（对照组）。排除标准为：存在其他全身性疾病或状况（如糖尿病）、有牙周炎治疗史、过去3个月内使用过抗生素、使用药物。通过问卷获取社会人口统计学数据。至少有8颗牙齿的参与者接受全口检查，评估菌斑指数（API）、牙龈出血指数（PBI）、探诊深度（PPD）、附着丧失（REC）和临床附着丧失（CAL）。CLL患者的医疗数据从患者记录中收集，而血液学数据从血常规中获取。
结果
两组在年龄、牙齿数量和牙科检查频率方面差异具有统计学意义（p<0.05）。与对照组相比，CLL患者的牙周指数平均值显著更高（API 0.81±0.18；PBI 2.72±0.68；PPD 3.40±0.53；REC 1.95±0.87，CAL 4.37±0.80）（对照组：API 0.69±0.15；PBI 1.91±0.45；PPD 2.51±0.40；REC 0.99±0.54；CAL 3.00±0.58）。年龄与牙周指数之间的相关系数显示年龄与REC（r=0.357；p<0.01）以及年龄与CAL（r=0.295；p<0.05）之间具有统计学意义。年龄对CAL不是具有统计学意义的协变量（F=2.205；p>0.05），仅对REC是（F=4.601；p<0.05）。去除年龄的统计效应后，CLL组与对照组在REC方面的差异仍具有统计学意义（F=19.732；p<0.01；η²=0.287）。未发现CLL患者的牙周参数与血液学参数之间存在统计学意义的关联（p>0.05）。
结论
本研究结果表明，与健康受试者相比，CLL患者的牙周状况更差。未证实牙周参数与血液学参数之间存在因果关系。
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