Department of Mechanical Engineering, McGill University, Montreal, QC, Canada.
Macromol Biosci. 2012 Feb;12(2):202-10. doi: 10.1002/mabi.201100335. Epub 2011 Dec 6.
Hybrid HA/Ge hydrogel particles are embedded in a secondary HA network to improve their structural integrity. The internal microstructure of the particles is imaged through TEM. CSLM is used to identify the location of the Ge molecules in the microgels. Through indentation tests, the Young's modulus of the individual particles is found to be 22 ± 2.5 kPa. The overall shear modulus of the composite is 75 ± 15 Pa at 1 Hz. The mechanical properties of the substrate are found to be viable for cell adhesion. The particles' diameter at pH = 8 is twice that at pH = 5. The pH sensitivity is found to be appropriate for smart drug delivery. Based on their mechanical and structural properties, HA-Ge hierarchical materials may be well suited for use as injectable biomaterials for tissue reconstruction.
杂化 HA/Ge 水凝胶颗粒嵌入到二次 HA 网络中,以提高其结构完整性。通过 TEM 对颗粒的内部微观结构进行成像。CSLM 用于识别微凝胶中 Ge 分子的位置。通过压痕试验,发现单个颗粒的杨氏模量为 22±2.5kPa。在 1Hz 时,复合材料的整体剪切模量为 75±15Pa。发现基底的力学性能适合细胞黏附。在 pH=8 时,颗粒的直径是 pH=5 时的两倍。发现其 pH 敏感性适合智能药物输送。基于其机械和结构性能,HA-Ge 分级材料可能非常适合用作组织重建的可注射生物材料。