Division of Haematology/Oncology, Department of Pediatric Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Pediatr Blood Cancer. 2012 Apr;58(4):492-7. doi: 10.1002/pbc.23419. Epub 2011 Dec 6.
Uneven strides in research and care have led to discrepancies in childhood cancer outcomes between high and low income countries (LICs). Collaborative research may help improve outcomes in LICs by generating knowledge for local scientific communities, augmenting knowledge translation, and fostering context-specific evaluation of treatment protocols. However, the risks of such research have received little attention. This paper investigates the relationship between pediatric oncology research in LICs and four core issues in the ethics literature: standard of care, trial benefits, ethics review, and informed consent. Our aims are to highlight the importance of this field and the need for further inquiry.
高收入国家和低收入国家（LICs）之间在儿童癌症研究和治疗方面的不平衡，导致了儿童癌症结果的差异。合作研究可以通过为当地科学界提供知识、增强知识转化以及促进治疗方案的具体情况评估，来帮助改善 LICs 的结果。然而，此类研究的风险却很少受到关注。本文探讨了 LICs 中的儿科肿瘤学研究与伦理文献中的四个核心问题之间的关系：护理标准、试验获益、伦理审查和知情同意。我们的目的是强调这一领域的重要性和进一步探究的必要性。
