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Effect of Melothria maderaspatana on carbon tetrachloride-induced changes in rat hepatic microsomal drug-metabolizing enzyme activity.

作者信息

Jayatilaka K A, Thabrew M I, Perera D J

机构信息

Department of Biochemistry, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.

出版信息

J Ethnopharmacol. 1990 Aug;30(1):97-105. doi: 10.1016/0378-8741(90)90020-t.

DOI:10.1016/0378-8741(90)90020-t
PMID:2214827
Abstract

Treatment with an aqueous extract of the aerial parts of Melothria maderaspatana, before or after CCl4 administration in rats markedly decreased CCl4-mediated reductions in aniline hydroxylase and p-aminopyrine N-demethylase activities. Phenobarbital-induced sleeping time in rats and kinetic enzyme studies showed that the effect of the plant was neither due to an induction of the drug metabolizing enzymes nor due to an alteration in the Km values of the enzymes.

摘要

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