Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700 032, India.
Saudi Pharm J. 2010 Jul;18(3):173-8. doi: 10.1016/j.jsps.2010.05.009. Epub 2010 Jun 2.
Antihyperglycemic and hypolipidemic effects of ethanol extract of aerial parts of Melothria maderaspatana and Coccinia indica were evaluated in STZ induced diabetes in Sprague-Dawley rats. The rats were concurrently treated with 100 or 200 mg/kg b.w. p.o. for 14 days. The changes in fasting blood glucose level and body weight were measured in 5 days interval. After 14 days experimental period, rats were sacrificed by cervical decapitation, blood and liver samples were collected. Biochemical estimation of plasma glucose, cholesterol, triglycerides, LDL, HDL, SGOT, SGPT and ALP were done from blood sample. The liver glycogen content was estimated using standard procedure from homogenized liver sample. Administration of EEMm or EECi to STZ-diabetic rats caused significant antihyperglycemic and hypolipidemic effects (p < 0.001). The extracts were also found to be significantly effective (p < 0.001; p < 0.05) on recovery of altered biochemical parameters and decreased body weight in treated animals. Glibenclamide (0.5 mg/kg b.w.) was used as standard in present study.
评价了白花茄子和印度南瓜地上部分乙醇提取物对链脲佐菌素诱导的糖尿病大鼠的降血糖和降血脂作用。大鼠同时给予 100 或 200mg/kg 体重，po，14 天。在 5 天的间隔内测量空腹血糖水平和体重变化。在 14 天的实验期结束后，通过颈椎脱臼处死大鼠，采集血液和肝脏样本。从血液样本中进行血浆葡萄糖、胆固醇、甘油三酯、LDL、HDL、SGOT、SGPT 和 ALP 的生化估计。使用标准程序从匀浆肝样本中估计肝糖原含量。向 STZ 糖尿病大鼠给予 EEMm 或 EECi 可显著降低血糖和血脂（p<0.001）。提取物还对恢复生化参数和降低治疗动物的体重有显著效果（p<0.001；p<0.05）。在本研究中，格列本脲（0.5mg/kg 体重）用作标准。
