Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan.
J Nat Prod. 2012 Jan 27;75(1):22-5. doi: 10.1021/np2004193. Epub 2011 Dec 12.
Four novel benzo[j]fluoranthene derivatives, hypoxylonols C (3), D (4), E (5), and F (6), have been isolated from the mushroom Hypoxylon truncatum, together with two known benzo[j]fluoranthene derivatives, hypoxylonols A (1) and B (2). The structures were established by analysis of NMR spectroscopic data and X-ray diffraction data. Compounds 4 and 5 showed antiproliferative activity against HUVECs (human umbilical vein endothelial cells) and HUAECs (human umbilical artery endothelial cells).
从 Hypoxylon truncatum 蘑菇中分离得到了 4 种新型苯并[j]荧蒽衍生物，分别为 hypoxylonols C（3）、D（4）、E（5）和 F（6），此外还分离得到了两种已知的苯并[j]荧蒽衍生物 hypoxylonols A（1）和 B（2）。通过分析 NMR 光谱数据和 X 射线衍射数据确定了这些化合物的结构。化合物 4 和 5 对 HUVECs（人脐静脉内皮细胞）和 HUAECs（人脐动脉内皮细胞）具有抗增殖活性。
