Thodberg Hans Henrik, Jenni Oskar G, Ranke Michael B, Martin David D
Visiana, Holte, Denmark.
Ann Hum Biol. 2012 Jan;39(1):68-75. doi: 10.3109/03014460.2011.642405. Epub 2011 Dec 12.
BACKGROUND/AIMS: The Tanner-Whitehouse (TW) method for bone age determination has been the basis for many population studies and it is used in many clinics. However, TW bone age raters can differ systematically from each other. The aim of the study was to present a new standard version of TW bone age rating implemented by the automated BoneXpert method and calibrated on the manual TW stage ratings of the First Zurich Longitudinal Study.
Hand radiographs of 231 children born in 1954-1956 were recorded annually from an average age of 5-20 years. For validation, 76 X-rays of Tanner's original Gold Series from eight boys were used.
The root mean square deviation between manual and automated TW ratings in the Zurich data was 0.67 years for boys in the TW bone age range 5-15 years and 0.63 years for girls, 5-14 years. The new standard TW rating differs systematically from two previous TW versions of the automated method, based on different raters.
The new automated TW ratings show good accuracy relative to the manual ratings of the Zurich data and the Gold Series. There are significant differences between manual TW raters, an effect which is eliminated with the automated method.
背景/目的：坦纳-怀特豪斯（TW）骨龄测定方法一直是许多人群研究的基础，并且在许多诊所中使用。然而，TW骨龄评估者之间可能存在系统性差异。本研究的目的是展示一种由自动化BoneXpert方法实施并根据苏黎世第一纵向研究的手动TW阶段评级进行校准的TW骨龄评估新标准版本。
对1954年至1956年出生的231名儿童的手部X光片进行了记录，记录时间为从平均5岁至20岁期间的每年。为了进行验证，使用了来自八个男孩的坦纳原始黄金系列中的76张X光片。
在苏黎世数据中，对于TW骨龄范围为5至15岁的男孩，手动和自动TW评级之间的均方根偏差为0.67岁，对于5至14岁的女孩为0.63岁。新的标准TW评级与基于不同评估者的之前两个自动化方法的TW版本存在系统性差异。
相对于苏黎世数据和黄金系列的手动评级，新的自动化TW评级显示出良好的准确性。手动TW评估者之间存在显著差异，而自动化方法消除了这种影响。
