Centre for Ethics in Medicine, University of Bristol, UK.
Bioethics. 2013 May;27(4):175-85. doi: 10.1111/j.1467-8519.2011.01931.x. Epub 2011 Dec 13.
Despite intense academic debate in the recent past over the use of 'sham surgery' control groups in research, there has been a recent resurgence in their use in the field of neurodegenerative disease. Yet the primacy of ethical arguments in favour of sham surgery controls is not yet established. Preliminary empirical research shows an asymmetry between the views of neurosurgical researchers and patients on the subject, while different ethical guidelines and regulations support conflicting interpretations. Research ethics committees faced with a proposal involving sham surgery should be aware of its ethical complexities. An overview of recent and current placebo-controlled surgical trials in the field of Parkinson's Disease is provided here, followed by an analysis of the key ethical issues which such trials raise.
尽管在最近的过去，学术界对在研究中使用“假手术”对照组存在激烈的争论，但在神经退行性疾病领域，最近又重新开始使用这种方法。然而，支持假手术对照的伦理论点的首要地位尚未确立。初步的实证研究表明，神经外科研究人员和患者对此问题的看法存在不对称，而不同的伦理准则和规定则支持相互冲突的解释。面对涉及假手术的提案，研究伦理委员会应该意识到其伦理复杂性。本文提供了该领域中最近和当前的帕金森病安慰剂对照手术试验的概述，接着分析了此类试验提出的关键伦理问题。
