Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
Eur J Neurol. 2012 Apr;19(4):594-602. doi: 10.1111/j.1468-1331.2011.03586.x. Epub 2011 Dec 10.
To analyze previously established gender differences in cervical artery dissection (CeAD).
This case-control study is based on the CADISP (Cervical Artery Dissection and Ischemic Stroke Patients) population comprising 983 consecutive CeAD patients (mean age: 44.1 ± 9.9 years) and 658 control patients with a non-CeAD ischemic stroke (IS) (44.5 ± 10.5 years).
Cervical artery dissection was more common in men (56.7% vs. 43.3%, P < 0.001) and men were older (46.4 vs. 41.0 years, P < 0.001). We assessed putative risk factors for CeAD including vascular risk factors, recent cervical trauma, pregnancies, and infections. All gender differences in the putative risk factors and outcome were similar in the CeAD and the non-CeAD IS groups.
Our analysis of the largest collection of CeAD patients to date confirms male predominance and differences in age at dissection between men and women. Gender differences in putative risk factors may explain the higher frequency of CeAD in men and their older age, but the putative risk factors are probably not specific for CeAD.
分析已建立的颈内动脉夹层（CeAD）的性别差异。
本病例对照研究基于 CADISP（颈内动脉夹层和缺血性卒中患者）人群，包括 983 例连续的 CeAD 患者（平均年龄：44.1±9.9 岁）和 658 例非 CeAD 缺血性卒中（IS）患者（44.5±10.5 岁）。
颈内动脉夹层在男性中更为常见（56.7% vs. 43.3%，P<0.001），男性年龄更大（46.4 岁 vs. 41.0 岁，P<0.001）。我们评估了颈内动脉夹层的潜在危险因素，包括血管危险因素、近期颈椎外伤、妊娠和感染。颈内动脉夹层和非颈内动脉夹层 IS 组的所有潜在危险因素和结局的性别差异相似。
我们对迄今为止最大的颈内动脉夹层患者群体的分析证实了男性优势和男性与女性夹层年龄的差异。潜在危险因素的性别差异可能解释了男性颈内动脉夹层的更高频率及其年龄更大，但潜在危险因素可能不是颈内动脉夹层特有的。
