Diabetes Research, Department of Cardiovascular Sciences, University of Leicester, University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary, Leicester LE1 5WW, UK.
BMC Public Health. 2011 Dec 8;11:908. doi: 10.1186/1471-2458-11-908.
The rising prevalence of Type 2 Diabetes Mellitus (T2DM) is a major public health problem. There is an urgent need for effective lifestyle interventions to prevent the development of T2DM. Sedentary behaviour (sitting time) has recently been identified as a risk factor for diabetes, often independent of the time spent in moderate-to-vigorous physical activity. Project STAND (Sedentary Time ANd Diabetes) is a study which aims to reduce sedentary behaviour in younger adults at high risk of T2DM.
METHODS/DESIGN: A reduction in sedentary time is targeted using theory driven group structured education. The STAND programme is subject to piloting and process evaluation in line with the MRC framework for complex interventions. Participants are encouraged to self-monitor and self-regulate their behaviour. The intervention is being assessed in a randomised controlled trial with 12 month follow up. Inclusion criteria are a) aged 18-40 years with a BMI in the obese range; b) 18-40 years with a BMI in the overweight range plus an additional risk factor for T2DM. Participants are randomised to the intervention (n = 89) or control (n = 89) arm. The primary outcome is a reduction in sedentary behaviour at 12 months as measured by an accelerometer (count < 100/min). Secondary outcomes include physical activity, sitting/lying time using the ActivPAL posture monitor, fasting and 2 h oral glucose tolerance test, lipids, inflammatory biomarkers, body weight, waist circumference, blood pressure, illness perceptions, and efficacy beliefs for behaviour change.
This is the first UK trial to address sedentary behaviour change in a population of younger adults at risk of T2DM. The results will provide a platform for the development of a range of future multidisciplinary interventions in this rapidly expanding high-risk population.
Current controlled trials ISRCTN08434554, MRC project 91409.
2 型糖尿病（T2DM）的患病率不断上升，是一个主要的公共卫生问题。急需有效的生活方式干预措施来预防 T2DM 的发生。久坐行为（坐的时间）最近被确定为糖尿病的一个危险因素，通常独立于中等到剧烈体力活动所花费的时间。Project STAND（久坐时间与糖尿病）是一项旨在降低 T2DM 高危年轻成年人久坐行为的研究。
方法/设计：使用基于理论的小组结构化教育来减少久坐时间。STAND 计划正在根据 MRC 复杂干预框架进行试点和过程评估。鼓励参与者自我监测和自我调节行为。该干预措施正在一项随机对照试验中进行评估，随访时间为 12 个月。纳入标准为：a）年龄在 18-40 岁之间，BMI 在肥胖范围内；b）年龄在 18-40 岁之间，BMI 在超重范围内，外加 T2DM 的另一个危险因素。参与者被随机分配到干预组（n=89）或对照组（n=89）。主要结局是通过加速度计测量的 12 个月时久坐行为减少（计数<100/min）。次要结局包括身体活动、使用 ActivPAL 姿势监测仪的坐/躺时间、空腹和 2 小时口服葡萄糖耐量试验、血脂、炎症生物标志物、体重、腰围、血压、疾病感知和行为改变的疗效信念。
这是英国首例针对 T2DM 高危年轻成年人久坐行为改变的试验。研究结果将为这一快速扩张的高危人群中一系列未来多学科干预措施的发展提供平台。
当前对照试验 ISRCTN08434554，MRC 项目 91409。
