Diabetes Research Centre, University of Leicester, Leicester LE5 4PW, UK.
NIHR Leicester Biomedical Research Centre, Leicester LE5 4PW, UK.
Int J Environ Res Public Health. 2021 Jun 8;18(12):6210. doi: 10.3390/ijerph18126210.
Isotemporal substitution modelling (ISM) and compositional isotemporal modelling (CISM) are statistical approaches used in epidemiology to model the associations of replacing time in one physical behaviour with time in another. This study's aim was to use both ISM and CISM to examine and compare associations of reallocating 60 min of sitting into standing or stepping with markers of cardiometabolic health. Cross-sectional data collected during three randomised control trials (RCTs) were utilised. All participants ( = 1554) were identified as being at high risk of developing type 2 diabetes. Reallocating 60 min from sitting to standing and to stepping was associated with a lower BMI, waist circumference, and triglycerides and higher high-density lipoprotein cholesterol using both ISM and CISM ( < 0.05). The direction and magnitude of significant associations were consistent across methods. No associations were observed for hemoglobin A1c, total cholesterol, or low-density lipoprotein cholesterol for either method. Results of both ISM and CISM were broadly similar, allowing for the interpretation of previous research, and should enable future research in order to make informed methodological, data-driven decisions.
等时替代建模（ISM）和组成等时建模（CISM）是流行病学中用于模拟将一种身体行为中的时间替换为另一种时间的关联的统计方法。本研究的目的是使用 ISM 和 CISM 来检查和比较将 60 分钟的坐姿重新分配为站立或行走与心血管代谢健康标志物之间的关联。该研究使用了三项随机对照试验（RCT）期间收集的横断面数据。所有参与者（n=1554）都被认为有患 2 型糖尿病的高风险。使用 ISM 和 CISM 均表明，将 60 分钟的坐姿重新分配为站立和行走与较低的 BMI、腰围和甘油三酯以及较高的高密度脂蛋白胆固醇相关（<0.05）。两种方法的显著关联的方向和幅度一致。两种方法均未观察到血红蛋白 A1c、总胆固醇或低密度脂蛋白胆固醇的关联。ISM 和 CISM 的结果大致相似，允许对先前的研究进行解释，并应能够为未来的研究提供信息，以便做出明智的方法学、数据驱动的决策。
