University Institute of Pharmacy, Pt. Ravishankar Shukla University Raipur, Chhattisgarh, India.
J Cosmet Dermatol. 2011 Dec;10(4):260-5. doi: 10.1111/j.1473-2165.2011.00586.x.
Ultraviolet radiations generate reactive oxygen species, leading to adverse effects on skin properties. Botanical extracts are multifunctional in nature having various properties like photoprotection, anti-aging, moisturizing, antioxidant, astringent, anti-irritant, and antimicrobial activity.
The aim of this study was to formulate creams having Curcuma longa extract loaded novel vesicular systems (liposomes, ethosomes, and transfersomes) and study their photoprotective effect by assessment of skin hydration (Cutometer) and sebum content (Sebumeter).
The alcoholic C. longa extract loaded liposomes, ethosomes, and transfersomes having 0.5-2.0% w/w extract were prepared, evaluated for size, entrapment efficiency, and incorporated into the cream. Their long-term interaction with skin (6 weeks) was compared in terms of their effects on skin hydration and sebum content.
Vesicular size obtained was in the range 167.3 ± 3.0 to 262.4 ± 2.4 nm with low polydispersity index (0.2-0.3) and high entrapment efficiency. The efficacy was in the order C. longa extract loaded transfersomal creams > C. longa extract loaded ethosomal creams > C. longa extract loaded liposomal creams > C. longa extract loaded creams > Empty transfersome loaded cream > Empty ethosome loaded cream > Empty liposome loaded cream > Base cream.
The photoprotective properties of the constituents of C. longa extract and hydrant, moisturizing lipid components of nano vesicles with better skin penetration resulted in improvement in skin properties like skin hydration and sebum content. The herbal extract loaded nano vesicles incorporated in cream could be used as photoprotective formulations.
紫外线辐射会产生活性氧物种，对皮肤性质造成不利影响。植物提取物具有多种功能，具有多种特性，如光保护、抗老化、保湿、抗氧化、收敛、抗刺激和抗菌活性。
本研究的目的是制备含有姜黄提取物的新型囊泡系统（脂质体、醇质体和传递体）的乳膏，并通过评估皮肤水合作用（皮肤水分计）和皮脂含量（皮脂计）来研究其光保护作用。
制备载有姜黄提取物的醇质体、脂质体和传递体，载药量为 0.5-2.0%w/w，评价其粒径、包封率，并将其掺入乳膏中。比较其与皮肤的长期相互作用（6 周），考察其对皮肤水合作用和皮脂含量的影响。
囊泡粒径为 167.3±3.0-262.4±2.4nm，多分散指数低（0.2-0.3），包封率高。功效顺序为：姜黄提取物负载传递体乳膏>姜黄提取物负载醇质体乳膏>姜黄提取物负载脂质体乳膏>姜黄提取物负载乳膏>空白传递体负载乳膏>空白醇质体负载乳膏>空白脂质体负载乳膏>基础乳膏。
姜黄提取物的防晒成分和保湿、滋润纳米囊泡的脂质成分具有更好的皮肤穿透性，改善了皮肤的水合作用和皮脂含量等性质。含有纳米囊泡的草药提取物的乳膏可作为光保护制剂使用。
