鉴定控制能量代谢的新型转录因子。
Identifying novel transcriptional components controlling energy metabolism.
机构信息
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Cell Metab. 2011 Dec 7;14(6):739-45. doi: 10.1016/j.cmet.2011.11.007.
Abstract
The investigation of metabolic regulation at the transcriptional level presents different challenges than those encountered in the study of other important problems like development or cancer. Levels of key components like glucose, insulin, and lipids can be modulated but rarely change in an all-or-none fashion, necessitating quantitative techniques that can be applied to multiple tissues and systems. This review examines recent advances in methods for studying transcriptional regulation, with special emphasis on metabolic science. We compare these methods for investigators trying to decide on the best approach for their particular physiological paradigm or model system.
摘要
在转录水平上研究代谢调控所面临的挑战与研究发育或癌症等其他重要问题所面临的挑战不同。关键成分（如葡萄糖、胰岛素和脂质）的水平可以调节，但很少以全有或全无的方式变化，这就需要能够应用于多种组织和系统的定量技术。本文综述了研究转录调控的最新方法进展，特别强调了代谢科学。我们比较了这些方法，以供研究人员在决定其特定生理范例或模型系统的最佳方法时参考。
相似文献
1
Identifying novel transcriptional components controlling energy metabolism.鉴定控制能量代谢的新型转录因子。
Cell Metab. 2011 Dec 7;14(6):739-45. doi: 10.1016/j.cmet.2011.11.007.
2
Serial analysis of binding elements for transcription factors.转录因子结合元件的序列分析
Methods Mol Biol. 2009;567:113-32. doi: 10.1007/978-1-60327-414-2_8.
3
A probabilistic dynamical model for quantitative inference of the regulatory mechanism of transcription.一种用于转录调控机制定量推断的概率动力学模型。
Bioinformatics. 2006 Jul 15;22(14):1753-9. doi: 10.1093/bioinformatics/btl154. Epub 2006 Apr 21.
4
Inferring quantitative models of regulatory networks from expression data.从表达数据推断调控网络的定量模型。
Bioinformatics. 2004 Aug 4;20 Suppl 1:i248-56. doi: 10.1093/bioinformatics/bth941.
5
Biological data warehousing system for identifying transcriptional regulatory sites from gene expressions of microarray data.用于从微阵列数据的基因表达中识别转录调控位点的生物数据仓库系统。
IEEE Trans Inf Technol Biomed. 2006 Jul;10(3):550-8. doi: 10.1109/titb.2005.862466.
6
A systematic model to predict transcriptional regulatory mechanisms based on overrepresentation of transcription factor binding profiles.一种基于转录因子结合谱过度表征来预测转录调控机制的系统模型。
Genome Res. 2006 Mar;16(3):405-13. doi: 10.1101/gr.4303406. Epub 2006 Jan 31.
7
The role of chromatin during transcription.染色质在转录过程中的作用。
Cell. 2007 Feb 23;128(4):707-19. doi: 10.1016/j.cell.2007.01.015.
8
The post-genomic era: workshop on chromatin immunoprecipitation-related techniques.后基因组时代：染色质免疫沉淀相关技术研讨会
Cell Death Differ. 2007 Jul;14(7):1390-1. doi: 10.1038/sj.cdd.4402164. Epub 2007 May 18.
9
Identifying pattern-defined regulatory islands in mammalian genomes.识别哺乳动物基因组中模式定义的调控岛。
Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10116-21. doi: 10.1073/pnas.0704028104. Epub 2007 May 29.
10
Predictive regulatory models in Drosophila melanogaster by integrative inference of transcriptional networks.通过整合转录网络推断，预测果蝇中的调控模型。
Genome Res. 2012 Jul;22(7):1334-49. doi: 10.1101/gr.127191.111. Epub 2012 Mar 28.
引用本文的文献
1
Metabolic differences in MSTN and FGF5 dual-gene edited sheep muscle cells during myogenesis.成肌过程中 MSTN 和 FGF5 双基因编辑绵羊肌肉细胞的代谢差异。
BMC Genomics. 2024 Jun 26;25(1):637. doi: 10.1186/s12864-024-10494-w.
2
Adipocyte Specific HO-1 Gene Therapy is Effective in Antioxidant Treatment of Insulin Resistance and Vascular Function in an Obese Mice Model.脂肪细胞特异性HO-1基因疗法在肥胖小鼠模型中对胰岛素抵抗和血管功能的抗氧化治疗有效。
Antioxidants (Basel). 2020 Jan 1;9(1):40. doi: 10.3390/antiox9010040.
3
Modulation of Glucose Metabolism in Hippocampal Neurons by Adiponectin and Resistin.脂联素和抵抗素对海马神经元葡萄糖代谢的调节。
Mol Neurobiol. 2019 Apr;56(4):3024-3037. doi: 10.1007/s12035-018-1271-x. Epub 2018 Aug 3.
4
Global Transcriptome Analysis of Brown Adipose Tissue of Diet-Induced Obese Mice.饮食诱导肥胖小鼠棕色脂肪组织的全转录组分析。
Int J Mol Sci. 2018 Apr 6;19(4):1095. doi: 10.3390/ijms19041095.
5
Transcriptional coregulators: fine-tuning metabolism.转录共调节因子：微调新陈代谢。
Cell Metab. 2014 Jul 1;20(1):26-40. doi: 10.1016/j.cmet.2014.03.027. Epub 2014 May 1.
6
A metabolic link to skeletal muscle wasting and regeneration.骨骼肌萎缩与再生的代谢联系。
Front Physiol. 2014 Feb 3;5:32. doi: 10.3389/fphys.2014.00032. eCollection 2014.
7
Dual functions of TAF7L in adipocyte differentiation.TAF7L在脂肪细胞分化中的双重功能。
Elife. 2013 Jan 8;2:e00170. doi: 10.7554/eLife.00170.
8
Hkat, a novel nutritionally regulated transmembrane protein in adipose tissues.脂肪组织中一种新型的营养调控跨膜蛋白 Hkat。
Sci Rep. 2012;2:825. doi: 10.1038/srep00825. Epub 2012 Nov 14.
9
Nrac, a novel nutritionally-regulated adipose and cardiac-enriched gene.Nrac，一种新型的营养调节脂肪和心脏丰富的基因。
PLoS One. 2012;7(9):e46254. doi: 10.1371/journal.pone.0046254. Epub 2012 Sep 27.
10
Elevation of transcription factor Islet-1 levels in vivo increases β-cell function but not β-cell mass.体内转录因子 Islet-1 水平的升高可增加β细胞功能，但不增加β细胞数量。
Islets. 2012 May-Jun;4(3):199-206. doi: 10.4161/isl.19982. Epub 2012 May 1.
本文引用的文献
1
Fasting of 3-day-old chicks leads to changes in histone H3 methylation status.断食 3 日龄雏鸡导致组蛋白 H3 甲基化状态的改变。
Physiol Behav. 2012 Jan 18;105(2):276-82. doi: 10.1016/j.physbeh.2011.06.023. Epub 2011 Jul 29.
2
Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA.通过功能定义的不同类别增强子重编程转录，这些增强子由 eRNA 定义。
Nature. 2011 May 15;474(7351):390-4. doi: 10.1038/nature10006.
3
A user's guide to the encyclopedia of DNA elements (ENCODE).DNA 元件百科全书（ENCODE）使用指南
PLoS Biol. 2011 Apr;9(4):e1001046. doi: 10.1371/journal.pbio.1001046. Epub 2011 Apr 19.
4
Extensive chromatin remodelling and establishment of transcription factor 'hotspots' during early adipogenesis.在早期脂肪生成过程中，广泛的染色质重塑和转录因子“热点”的建立。
EMBO J. 2011 Apr 20;30(8):1459-72. doi: 10.1038/emboj.2011.65. Epub 2011 Mar 22.
5
Cross species comparison of C/EBPα and PPARγ profiles in mouse and human adipocytes reveals interdependent retention of binding sites.比较鼠与人脂肪细胞中 C/EBPα 和 PPARγ 的特征，揭示了结合位点的相互依存保留。
BMC Genomics. 2011 Mar 16;12:152. doi: 10.1186/1471-2164-12-152.
6
Species-specific strategies underlying conserved functions of metabolic transcription factors.代谢转录因子保守功能背后的物种特异性策略。
Mol Endocrinol. 2011 Apr;25(4):694-706. doi: 10.1210/me.2010-0454. Epub 2011 Feb 3.
7
RNA sequencing: advances, challenges and opportunities.RNA 测序：进展、挑战和机遇。
Nat Rev Genet. 2011 Feb;12(2):87-98. doi: 10.1038/nrg2934. Epub 2010 Dec 30.
8
C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling.C/EBPβ 控制运动引起的心脏生长并防止病理性心脏重构。
Cell. 2010 Dec 23;143(7):1072-83. doi: 10.1016/j.cell.2010.11.036.
9
Comprehensive analysis of the chromatin landscape in Drosophila melanogaster.全面分析黑腹果蝇的染色质景观。
Nature. 2011 Mar 24;471(7339):480-5. doi: 10.1038/nature09725. Epub 2010 Dec 22.
10
Accurate inference of transcription factor binding from DNA sequence and chromatin accessibility data.从 DNA 序列和染色质可及性数据中准确推断转录因子结合。
Genome Res. 2011 Mar;21(3):447-55. doi: 10.1101/gr.112623.110. Epub 2010 Nov 24.
Zotero 插件