鉴定控制能量代谢的新型转录因子。
Identifying novel transcriptional components controlling energy metabolism.
机构信息
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Cell Metab. 2011 Dec 7;14(6):739-45. doi: 10.1016/j.cmet.2011.11.007.
Abstract
The investigation of metabolic regulation at the transcriptional level presents different challenges than those encountered in the study of other important problems like development or cancer. Levels of key components like glucose, insulin, and lipids can be modulated but rarely change in an all-or-none fashion, necessitating quantitative techniques that can be applied to multiple tissues and systems. This review examines recent advances in methods for studying transcriptional regulation, with special emphasis on metabolic science. We compare these methods for investigators trying to decide on the best approach for their particular physiological paradigm or model system.
摘要
在转录水平上研究代谢调控所面临的挑战与研究发育或癌症等其他重要问题所面临的挑战不同。关键成分（如葡萄糖、胰岛素和脂质）的水平可以调节，但很少以全有或全无的方式变化，这就需要能够应用于多种组织和系统的定量技术。本文综述了研究转录调控的最新方法进展，特别强调了代谢科学。我们比较了这些方法，以供研究人员在决定其特定生理范例或模型系统的最佳方法时参考。
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