Laboratory of Epidemiology and Prevention of Cardiovascular Disease, Faculty of Medicine, Tunis, Tunisia.
Eur J Intern Med. 2012 Jan;23(1):e5-9. doi: 10.1016/j.ejim.2011.10.011. Epub 2011 Nov 12.
C-reactive protein (CRP) is an independent risk factor of diabetes and cardiovascular disease and it is proposed as a component of metabolic syndrome (MS). This study was undertaken to investigate the relationship between CRP and various characteristics of the MS in a sample of the Tunisian population
One hundred and forty nine patients with MS and 152 controls, aged 35-70 years were recruited. Waist circumference (WC), blood pressure, HDL-cholesterol (HDL-C), triglycerides (TG), glucose, insulin and CRP were measured. Insulin resistance was assessed by homeostasis model assessment of insulin resistance (HOMA-IR). MS was defined by NCEP-ATPIII report
CRP levels were significantly higher in MS group (4.41±3.73 mg/L vs. 2.68±2.59 mg/L, p<0.001) compared to without MS group. For both sexes, CRP increased as the number of MS components increased (p=0.015 for men and p<0.001) after adjustment for age, smoking, alcohol intake and, for women, menopause. There were statistically significant positive correlations for log CRP with WC, log TG, and log HOMA-IR in both sexes adjusted for confounding factors listed above. A significant negative correlation was found between HDL-C and log CRP only in women. In both sexes, WC was identified, by multiple linear regression models, as significant independent predictor of CRP level variability. HDL-C showed also a significant contribution only in women
The present study provides evidence that CRP levels are elevated in MS subjects. In addition, WC and HDL-C are significant predictors of the CRP elevation.
C 反应蛋白（CRP）是糖尿病和心血管疾病的独立危险因素，它被认为是代谢综合征（MS）的一个组成部分。本研究旨在调查 CRP 与突尼斯人群样本中 MS 的各种特征之间的关系。
共招募了 149 例 MS 患者和 152 例对照者，年龄 35-70 岁。测量腰围（WC）、血压、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）、血糖、胰岛素和 CRP。采用稳态模型评估胰岛素抵抗（HOMA-IR）评估胰岛素抵抗。MS 按照 NCEP-ATPIII 报告定义。
与无 MS 组相比，MS 组的 CRP 水平明显更高（4.41±3.73 mg/L 与 2.68±2.59 mg/L，p<0.001）。对于男性和女性，CRP 随着 MS 成分数量的增加而增加（p=0.015 对于男性和 p<0.001），调整了年龄、吸烟、饮酒等因素，对于女性，还调整了绝经状态。在调整了上述混杂因素后，CRP 与 WC、TG 和 HOMA-IR 的对数呈显著正相关。仅在女性中发现 CRP 与 HDL-C 之间存在显著负相关。在两性中，WC 通过多元线性回归模型被确定为 CRP 水平变化的显著独立预测因子。HDL-C 仅在女性中也表现出显著的贡献。
本研究提供了证据表明 CRP 水平在 MS 患者中升高。此外，WC 和 HDL-C 是 CRP 升高的重要预测因子。
