Department of Psychology, School of Science and Technology, Loma Linda University, United States.
Physiol Behav. 2012 Feb 28;105(4):1092-7. doi: 10.1016/j.physbeh.2011.11.022. Epub 2011 Nov 29.
Deviations from normal blood pressure can lead to a number of physiological and behavioral complications. We tested the hypothesis that hyper- or hypotension is associated with significant differences in motor activity and coordination, anxiety levels, and spatial learning and memory in male and female mice. Compared to normotensive control mice, hypertensive mice were hyperactive and their performance was significantly worse on the rotarod (males only), cued learning (males only), spatial learning/re-learning, and spatial memory. Hypotensive mice of both genders swam more slowly and performed even worse than hypertensive mice on the rotarod, cued learning, spatial learning/re-learning, and spatial memory tasks. Across all phenotypes, females were generally more active than males in the open field and exhibited more anxiety-like behaviors in the elevated zero maze. Alterations in hemodynamics and/or neurovascular unit function may account for the observed behavioral changes in the hypo- and hypertensive mice.
血压异常可导致多种生理和行为并发症。我们检验了以下假说，即高血压或低血压与雄性和雌性小鼠的运动活动和协调性、焦虑水平以及空间学习和记忆方面的显著差异有关。与血压正常的对照小鼠相比，高血压小鼠表现出过度活跃，其在转棒（仅雄性）、线索学习（仅雄性）、空间学习/再学习和空间记忆方面的表现明显更差。两种性别的低血压小鼠游得更慢，在转棒、线索学习、空间学习/再学习和空间记忆任务中的表现甚至比高血压小鼠更差。在所有表型中，雌性在旷场中通常比雄性更活跃，并且在高架十字迷宫中表现出更多的类似焦虑的行为。血液动力学和/或神经血管单元功能的改变可能解释了高血压和低血压小鼠观察到的行为变化。
