阿魏酸具有肾毒性，而没食子酸在长期治疗慢性肾病时具有肾脏保护作用。
Ferulic acid is nephrodamaging while gallic acid is renal protective in long term treatment of chronic kidney disease.
机构信息
Department of Physical Therapy, College of Health Care, China Medical University, 91 Hsueh-Shih Road, Taichung 40202, Taiwan, ROC.
出版信息
Clin Nutr. 2012 Jun;31(3):405-14. doi: 10.1016/j.clnu.2011.11.003. Epub 2011 Dec 10.
BACKGROUNDS & AIMS: The long term therapeutic effect of ferulic acid (FA) and gallic acid (GA) in treatment of chronic kidney disease (CKD) has been lacking.
METHODS
Doxorubicin (DR, Adriamycin)-induced CKD rat model was established for this study.
RESULTS
DR significantly reduced levels of serum albumin, GOT, GPT, RBC, TNF-α, and urinary creatinine and elevated serum cholesterol, TG, BUN, creatinine, uric acid, WBC, platelet count, and IL-6. In DRCKD rats, FA and GA significantly increased kidney weight and glomerular volume. FA reduced glomerular filtration rate but GA did not. FA enhanced more collagen deposition than GA in renal cortex and glomeruli. Both FA and GA showed crucial hyperlipidemic activity. The inhibitory effects of FA and GA on MMP-2 were very comparable. GA suppressed MMP-2 more effectively than FA in DRCKD rats. Both FA and GA induced SOD elevation and MDA elimination. In DRCKD rats, Western blot analysis indicated that FA further up-regulated CD34, α-SMA, tissue pDGFR, p-PDGFR, and TGF-β; and down-regulated p-PI3K, and p-Akt. Since both PDGF-BB and TGF-β are considered to induce kidney prefibrosis stage, GA was proved to be more beneficial in this regard.
CONCLUSIONS
GA tends to protect the CKD while FA is not recommended for the long term CKD therapy.
背景与目的
阿魏酸（FA）和没食子酸（GA）治疗慢性肾病（CKD）的长期疗效尚不清楚。
方法
本研究建立了多柔比星（DR，阿霉素）诱导的 CKD 大鼠模型。
结果
DR 显著降低了血清白蛋白、GOT、GPT、RBC、TNF-α和尿肌酐水平，升高了血清胆固醇、TG、BUN、肌酐、尿酸、WBC、血小板计数和 IL-6。在 DRCKD 大鼠中，FA 和 GA 显著增加了肾脏重量和肾小球体积。FA 降低了肾小球滤过率，但 GA 没有。FA 在肾皮质和肾小球中引起的胶原沉积比 GA 更多。FA 和 GA 均表现出关键的高脂血症活性。FA 和 GA 对 MMP-2 的抑制作用非常相似。GA 在 DRCKD 大鼠中比 FA 更有效地抑制 MMP-2。FA 和 GA 均诱导 SOD 升高和 MDA 消除。在 DRCKD 大鼠中，Western blot 分析表明，FA 进一步上调了 CD34、α-SMA、组织 pDGFR、p-PDGFR 和 TGF-β；并下调了 p-PI3K 和 p-Akt。由于 PDGF-BB 和 TGF-β 均被认为可诱导肾脏前纤维化阶段，因此 GA 在这方面更有益。
结论
GA 倾向于保护 CKD，而 FA 不建议用于长期 CKD 治疗。
Zotero 插件