芦丁（槲皮素芸香糖苷）可导致慢性肾脏病的蛋白质-能量营养不良，但槲皮素则有益处。
Rutin (quercetin rutinoside) induced protein-energy malnutrition in chronic kidney disease, but quercetin acted beneficially.
机构信息
Graduate Institute of Biotechnology, Changhua University of Education, Changhua, Taiwan.
出版信息
J Agric Food Chem. 2013 Jul 31;61(30):7258-67. doi: 10.1021/jf304595p. Epub 2013 Jul 22.
Nutraceutically, much of the literature has indicated that an aglycon and its related glycoside would act similarly. However, controversial reports are accumulating. We hypothesize that rutin (RT) and quercetin (QT) pharmacodynamically could act differently. To confirm this, doxorubicin (DR) (8.5 mg/kg) was used to induce rat chronic kidney disease (CKD) and then treated with QT and RT (each 70 mg/kg body weight per day) for 13 weeks. QT exhibited better body weight gaining effect (420 ± 45) vs RT, 350 ± 57 g/rat (p < 0.001). DR raised the ratio kidney-to-body weight (%) to 0.82 (p < 0.001) vs RT, 0.62 (p < 0.01), and QT, 0.35 (p < 0.01). DR reduced the glomerular filtration rate to 25.2 vs RT, 48 ± 11.3; QT, 124.7 ± 12.8 (p < 0.001) and the control, 191.5 ± 15.7 mL/h (p < 0.001). DRCKD reduced hematocrit to 29 ± 5; RT, to 28 ± 5 (p < 0.05); QT, to 36 ± 6 vs the control 37.5 ± 4%, (p < 0.01). DRCKD reduced the serum albumin (s-Ab) to 2.1 ± 0.2 (p < 0.001); QT, to 2.7 ± 0.2 (p < 0.05) vs the normal 4.3 ± 0.5 g/dL, yet RT was totally ineffective. DRCKD raised serum cholesterol level to 340 ± 30; vs RT, 260 ± 12; QT, 220 ± 25; and the normal value, 70 ± 25 mg/dL. DRCKD increased serum triglyceride to 260 ± 15 (p < 0.001), RT and QT restored it to 170 ± 25 and 200 ± 15 (p < 0.05) vs the normal 26-145 mg/dL. DRCKD elevated blood urea nitrogen to 38 ± 3 vs RT, to 98 ± 6 mg/dL (p < 0.001), implicating "protein-energy malnutrition". RT stimulated serum creatinine (sCr) production to reach 6.0 ± 0.9 mg/dL (p < 0.001). QT did not alter the sCr level. RT but not QT induced uremia and hypercreatininemia. DR significantly downregulated Bcl-2, but highly upregulated Bax, Bad, and cleaved caspase-3, implicating the intrinsic mitochondrial pathway. DR damaged DNA, but QT completely rescued such an effect and recovered renal amyloidosis and collagen deposition. Conclusively, RT and QT act differently, and RT is inferior to QT with respect to treating CKD.
在营养方面，大量文献表明糖苷配基及其相关糖苷会产生类似的作用。然而，争议性报告正在不断增加。我们假设芦丁（RT）和槲皮素（QT）在药效动力学上可能会有不同的作用。为了证实这一点，我们使用阿霉素（DR）（8.5mg/kg）诱导大鼠慢性肾病（CKD），然后用 QT 和 RT（每天每公斤体重 70mg）治疗 13 周。QT 表现出更好的体重增加效果（420±45）比 RT，350±57g/大鼠（p<0.001）。DR 将肾重与体重的比值提高到 0.82（p<0.001）比 RT，0.62（p<0.01），QT，0.35（p<0.01）。DR 将肾小球滤过率降低至 25.2 比 RT，48±11.3；QT，124.7±12.8（p<0.001）和对照，191.5±15.7mL/h（p<0.001）。DRCKD 将红细胞压积降低至 29±5；RT，至 28±5（p<0.05）；QT，至 36±6与对照 37.5±4%（p<0.01）。DRCKD 将血清白蛋白（s-Ab）降低至 2.1±0.2（p<0.001）；QT，至 2.7±0.2（p<0.05）与正常 4.3±0.5g/dL，而 RT 完全无效。DRCKD 将血清胆固醇水平提高至 340±30；比 RT，260±12；QT，220±25；和正常值，70±25mg/dL。DRCKD 将血清甘油三酯提高至 260±15（p<0.001），RT 和 QT 将其恢复至 170±25 和 200±15（p<0.05）与正常 26-145mg/dL。DRCKD 将血尿素氮提高至 38±3比 RT，至 98±6mg/dL（p<0.001），暗示“蛋白质能量营养不良”。RT 刺激血清肌酐（sCr）的产生达到 6.0±0.9mg/dL（p<0.001）。QT 并没有改变 sCr 水平。RT 但不是 QT 引起了尿毒症和高肌氨酸酐血症。DR 显著下调 Bcl-2，但高度上调 Bax、Bad 和 cleaved caspase-3，暗示了内在的线粒体途径。DR 损伤了 DNA，但 QT 完全挽救了这种作用，并恢复了肾脏淀粉样变性和胶原沉积。总之，RT 和 QT 作用不同，RT 在治疗 CKD 方面劣于 QT。
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