Science and Engineering of Oxidic Materialsand Nanomaterials, University Politehnica of Bucharest, Romania.
IEEE Trans Nanobioscience. 2011 Dec;10(4):269-74. doi: 10.1109/TNB.2011.2178263. Epub 2011 Dec 7.
Undesired biofilm development is a major concern in many areas, especially in the medical field. The purpose of the present study was to comparatively investigate the antibiofilm efficacy of usnic acid, in soluble versus nanofluid formulation, in order to highlight the potential use of Fe(3) O(4)/oleic acid (FeOA) nanofluid as potential controlled release vehicle of this antibiofilm agent. The (+) -UA loaded into nanofluid exhibited an improved antibiofilm effect on S. aureus biofilm formation, revealed by the drastic decrease of the viable cell counts as well as by confocal laser scanning microscopy images. Our results demonstrate that FeOA nanoparticles could be used as successful coating agents for obtaining antibiofilm pellicles on different medical devices, opening a new perspective for obtaining new antimicrobial and antibiofilm surfaces, based on hybrid functionalized nanostructured biomaterials.
在许多领域，特别是在医学领域，生物膜的不良发育是一个主要关注点。本研究的目的是比较研究地衣酸的抗生物膜功效，以可溶性形式与纳米流体形式，以突出 Fe(3)O(4)/油酸 (FeOA) 纳米流体作为这种抗生物膜剂的潜在控释载体的潜在用途。负载到纳米流体中的 (+)-UA 显示出对金黄色葡萄球菌生物膜形成的抗生物膜作用的改善，这通过活菌计数的急剧减少以及共聚焦激光扫描显微镜图像来揭示。我们的结果表明，FeOA 纳米粒子可用作获得不同医疗设备上抗生物膜薄膜的成功涂覆剂，为基于混合功能化纳米结构生物材料获得新的抗菌和抗生物膜表面开辟了新的视角。
