Department of Pediatric Immunology and Hematology, Necker Hospital, AP-HP, Paris, France.
Pediatrics. 2012 Jan;129(1):e199-203. doi: 10.1542/peds.2010-2739. Epub 2011 Dec 12.
Childhood multicentric Castleman disease (MCD) is a rare and unexplained lymphoproliferative disorder. We report a human herpesvirus-8 (HHV-8)-infected child, born to consanguineous Comorian parents, who displayed isolated MCD in the absence of any known immunodeficiency. We also systematically review the clinical features of the 32 children previously reported with isolated and unexplained MCD. The characteristics of this patient and the geographic areas of origin of most previous cases suggest that pediatric MCD is associated with HHV-8 infection. Moreover, as previously suggested for Kaposi sarcoma, MCD in childhood may result from inborn errors of immunity to HHV-8 infection.
儿童多中心 Castleman 病（MCD）是一种罕见且原因不明的淋巴组织增生性疾病。我们报告了一例由近亲科摩罗父母所生的人类疱疹病毒 8 型（HHV-8）感染患儿，其表现为孤立性 MCD，而无任何已知的免疫缺陷。我们还系统地回顾了此前报道的 32 例孤立性和原因不明的 MCD 患儿的临床特征。该患者的特征和大多数先前病例的起源地理区域表明，儿童 MCD 与 HHV-8 感染有关。此外，正如先前针对卡波西肉瘤所提出的那样，儿童 MCD 可能是由于对 HHV-8 感染的先天性免疫缺陷所致。
