Department of Cardiology, Biomedical Research (Therapy) Center, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
J Cardiovasc Pharmacol. 2012 Apr;59(4):387-96. doi: 10.1097/FJC.0b013e3182440338.
Endothelial progenitor cells were initially considered to radically alter the concepts of adult tissue angiogenesis for their contribution of incorporation into new blood vessels. Nevertheless, controversy arises over their mechanism of action due to rare cell population and decreased number and impaired activity under pathological changes. Recent studies show that endothelial progenitor cells also function in a paracrine manner by secreting multiple cytokines and growth factors, but the beneficial paracrine signals remain partially unidentified. In this review, we provide an overview of varieties and signal pathways of factors secreted by endothelial progenitor cells and further present the prospect of new ways to encourage cardiovascular protection such as neovascularization, reendothelialization of larger vessels, and myocardial remodeling based on the paracrine factors.
内皮祖细胞最初被认为通过整合到新血管中来彻底改变成人组织血管生成的概念。然而，由于其细胞数量稀少，数量减少和活性受损，它们的作用机制引起了争议。最近的研究表明，内皮祖细胞还通过分泌多种细胞因子和生长因子发挥旁分泌作用，但是有益的旁分泌信号仍部分未知。在这篇综述中，我们提供了内皮祖细胞分泌的因子的种类和信号通路的概述，并进一步根据旁分泌因子提出了鼓励心血管保护的新方法的前景，例如新血管生成，大血管的再内皮化和心肌重构。
