Multiple pulmonary metastases from giant cell tumor of a hand.

Giant cell tumor (GCT) of bone has been described as the most challenging benign bone tumors. The majority of these tumors, classically, are involved in the epiphysis of long bones; however, on rare occasions, the tumors occur in the small bones of hands and feet. Although this disorder is benign, GCTs show a tendency of significant bone destruction, local recurrence and, occasionally, pulmonary metastasis. Approximately 3% of GCTs is known to metastasize to the lung. Herein, the authors describe an extremely rare case of multiple pulmonary metastatic GCTs in a 54-year-old man who presented asymptomatic pulmonary nodular lesions detected incidentally on chest x-ray of routine health checkup. He underwent chemotherapy with adriamycin and cisplatin and achieved nearly complete remission.