National Institute for Health and Welfare, Department of Mental Health and Substance Abuse Services, P.O. Box 30, 00271 Helsinki, Finland.
Br J Psychiatry. 2012 Feb;200(2):143-9. doi: 10.1192/bjp.bp.111.094904. Epub 2011 Dec 8.
Mental disorders are associated with increased mortality, but population-based surveys with reliable diagnostic procedures controlling for somatic health status are scarce.
To assess excess mortality associated with depressive, anxiety and alcohol use disorders and the principal causes of death.
In a nationally representative sample of Finns aged 30-70 years, psychiatric disorders were diagnosed with the Composite International Diagnostic Interview. After an 8-year follow-up period, vital status and cause of death of each participant was obtained from national registers.
After adjusting for sociodemographic factors, health status and smoking, depressive (hazard ratio (HR) = 1.97) and alcohol use disorders (HR = 1.72) were statistically significantly associated with mortality. Risk of unnatural death was increased among individuals diagnosed with anxiety disorders or alcohol dependence.
Individuals with depressive and alcohol use disorders have an increased mortality risk comparable with many chronic somatic conditions, that is only partly attributable to differences in sociodemographic, somatic health status and hazardous health behaviour.
精神障碍与死亡率增加有关，但基于人群的调查，可靠的诊断程序控制躯体健康状况的研究却很少。
评估抑郁、焦虑和酒精使用障碍相关的超额死亡率以及主要死亡原因。
在一项对年龄在 30-70 岁的芬兰人进行的全国代表性样本中，使用复合国际诊断访谈对精神障碍进行了诊断。在 8 年的随访期后，从国家登记处获得了每位参与者的生存状况和死亡原因。
在调整了社会人口因素、健康状况和吸烟因素后，抑郁障碍（危险比 (HR) = 1.97）和酒精使用障碍（HR = 1.72）与死亡率有统计学显著关联。被诊断患有焦虑障碍或酒精依赖的个体，其非自然死亡风险增加。
患有抑郁和酒精使用障碍的个体的死亡率风险增加，与许多慢性躯体疾病相当，这部分归因于社会人口、躯体健康状况和危险健康行为的差异。
