Institute for Stem Cell Biology and Regenerative Medicine and Cancer Institute, Division of Haematology, Stanford University School of Medicine, Lokey Stem Cell Research Building, 265 Campus Drive, Stanford, California 94305, USA.
Nat Rev Cancer. 2011 Dec 8;12(1):58-67. doi: 10.1038/nrc3171.
The development of cancer involves mechanisms by which aberrant cells overcome normal regulatory pathways that limit their numbers and their migration. The evasion of programmed cell death is one of several key early events that need to be overcome in the progression from normal cellular homeostasis to malignant transformation. Recently, we provided evidence in mouse and human cancers that successful cancer clones must also overcome programmed cell removal. In this Opinion article, we explore the role of programmed cell removal in both normal and neoplastic cells, and we place this pathway in the context of the initiation of programmed cell death.
癌症的发展涉及到异常细胞克服限制其数量和迁移的正常调节途径的机制。逃避程序性细胞死亡是正常细胞稳态向恶性转化进展中需要克服的几个关键早期事件之一。最近，我们在小鼠和人类癌症中提供了证据，表明成功的癌症克隆还必须克服程序性细胞清除。在这篇观点文章中，我们探讨了程序性细胞清除在正常和肿瘤细胞中的作用，并将该途径置于程序性细胞死亡的启动背景下。
