Zhou Jiapei, Xiang Hongjie, Cao Zhiqun
First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
Department of Traditional Chinese Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
Front Oncol. 2023 Sep 27;13:1253191. doi: 10.3389/fonc.2023.1253191. eCollection 2023.
Let-7i regulates tumors primarily by binding to the 3' untranslated region (3' UTR) of mRNA, which indirectly regulates post-transcriptional gene expression. Let-7i also has an epigenetic function via modulating DNA methylation to directly regulate gene expression. Let-7i performs a dual role by inducing both the promotion and inhibition of various malignancies, depending on its target. The mechanism of Let-7i action involves cancer cell proliferation, migration, invasion, apoptosis, epithelial-mesenchymal transition, EV transmission, angiogenesis, autophagy, and drug resistance sensitization. Let-7i is closely related to cancer, and hence, is a potential biomarker for the diagnosis and prognosis of various cancers. Therapeutically, it can be used to promote an anti-cancer immune response by modifying exosomes, thus exerting a tumor-suppressive effect.
Let-7i主要通过与mRNA的3'非翻译区（3'UTR）结合来调节肿瘤，这间接调节转录后基因表达。Let-7i还通过调节DNA甲基化具有表观遗传功能，以直接调节基因表达。Let-7i通过诱导各种恶性肿瘤的促进和抑制发挥双重作用，这取决于其靶点。Let-7i的作用机制涉及癌细胞增殖、迁移、侵袭、凋亡、上皮-间质转化、细胞外囊泡传递、血管生成、自噬和耐药性致敏。Let-7i与癌症密切相关，因此是各种癌症诊断和预后的潜在生物标志物。在治疗方面，它可用于通过修饰外泌体来促进抗癌免疫反应，从而发挥肿瘤抑制作用。
