磷酸二酯酶抑制剂（罗利普兰）对人体 6-硫酸褪黑素尿排泄的影响。
Effects of a phosphodiesterase inhibitor (Rolipram) on the urinary excretion of 6-sulphatoxy melatonin in man.
机构信息
Maudsley Hospital, Denmark Hill, London, SE5.
出版信息
J Psychopharmacol. 1987 Jan;1(1):20-2. doi: 10.1177/026988118700100105.
PMID:22158749
Abstract
The urinary excretion of 6-sulphatoxymelatonin (aMT6s) from 2400 to 0600 h was significantly increased following the treatment of ten normal volunteers with a phospho diesterase inhibitor (rolipram 1 mg 8 h for 24 h). The urinary excretion of the metabolite from 0600 to 1200 h was significantly reduced after treatment with rolipram.
摘要
2400 至 0600 小时期间，10 名正常志愿者接受磷酸二酯酶抑制剂（罗利普兰 1 毫克，每 8 小时一次，共 24 小时）治疗后，6-硫酸褪黑素（aMT6s）的尿液排泄量显著增加。罗利普兰治疗后，0600 至 1200 小时期间代谢物的尿液排泄量显著减少。
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