Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health System, Portland, Oregon 97232, USA.
Invest Ophthalmol Vis Sci. 2011 Sep 9;52(10):7109-21. doi: 10.1167/iovs.11-7448.
To quantify the lamina cribrosa insertion into the peripapillary sclera and optic nerve pia in normal (N) and early experimental glaucoma (EEG) monkey eyes.
Perfusion-fixed optic nerve heads (ONHs) from 21 animals were digitally reconstructed three dimensionally and delineated. Anterior Laminar Insertion Position (ALIP), Posterior Laminar Insertion Position (PLIP), Laminar Insertion Length (LIL; distance between the anterior and posterior laminar insertions), and Scleral Thickness (at the Anterior Sub-arachnoid space) were calculated for each ONH. Animals were pooled into four groups based on the kill condition (N vs. EEG) and perfusion IOP (10, 30, or 45 mm Hg) of each eye: N10-N10 (n = 6), N30/45-N10 (n = 6), EEG10-N10 (n = 3), and EEG30/45-N10 (n = 6). Glaucomatous EEG versus N eye differences in each group and each animal were required not only to achieve statistical significance (P < 0.05) but also to exceed physiologic intereye differences within the bilaterally normal groups.
ALIP was significantly posterior (outward) in the EEG compared with N10 eyes of the EEG30/45-N10 group and 5 of 9 individual EEG eyes (difference range, 12-49 μm). PLIP was significantly posterior in the EEG eyes of both EEG groups and in 6 of 9 individual EEG eyes (range, 25-83 μm). LIL ranged from 90 to 190 μm in normal eyes and was significantly increased within the EEG eyes of both EEG groups and in 7 of 9 individual EEG eyes (difference range, 30-47 μm).
Posterior migration of the lamina cribrosa is a component of early cupping in monkey EEG.
定量分析正常（N）和早期实验性青光眼（EEG）猴眼的视盘周围巩膜和视神经软脑膜的筛板插入情况。
对 21 只动物的灌注固定视神经头（ONH）进行数字三维重建和描绘。计算每个 ONH 的前筛板插入位置（ALIP）、后筛板插入位置（PLIP）、筛板插入长度（前后筛板插入位置之间的距离）和巩膜厚度（前蛛网膜下腔）。根据处死条件（N 与 EEG）和每只眼的灌注眼压（10、30 或 45mmHg），将动物分为 4 组：N10-N10（n=6）、N30/45-N10（n=6）、EEG10-N10（n=3）和 EEG30/45-N10（n=6）。EEG 眼与 N 眼的差异在每组和每个动物中不仅需要达到统计学意义（P<0.05），而且需要超过双侧正常组内的生理眼间差异。
在 EEG30/45-N10 组的 EEG 眼和 9 只 EEG 眼中的 5 只中，ALIP 明显向后（向外），差异范围为 12-49μm。在两个 EEG 组的 EEG 眼中，PLIP 明显向后，在 9 只 EEG 眼中有 6 只（范围为 25-83μm）。在正常眼中，LIL 范围为 90-190μm，在两个 EEG 组的 EEG 眼中以及 9 只 EEG 眼中的 7 只明显增加（差异范围为 30-47μm）。
筛板向后迁移是猴 EEG 早期杯盘形成的一个组成部分。
