Laboratory of Complement Biology, New York Blood Center, New York, NY 10065, USA.
Hematology Am Soc Hematol Educ Program. 2011;2011:466-9. doi: 10.1182/asheducation-2011.1.466.
Some clinical studies have identified potential adverse patient outcomes associated with RBC storage length. This may in part be due to the release of potentially hazardous bioactive products that accumulate during storage and are delivered at high concentrations during transfusion. In this situation, a proinflammatory tissue microenvironment may be established that can alter immunoregulatory mechanisms. This review highlights some of the potential immunomodulatory effects of stored RBCs that may be responsible for adverse transfusion reactions.
一些临床研究已经确定了与红细胞储存时间相关的潜在不良患者结局。这可能部分归因于在储存过程中积累并在输血时以高浓度释放的潜在危险生物活性产物。在这种情况下，可能会建立一个促炎的组织微环境，从而改变免疫调节机制。本综述强调了储存的红细胞可能导致不良反应的一些潜在免疫调节作用。
