Garavelli P L, Ciriello M
Divisione di Malattie Infettive, Ospedale Civile, Alessandria.
Minerva Med. 1990 Jul-Aug;81(7-8 Suppl):109-10.
Modifications of the levels of T-helper (T4) and T-suppressor (T8) lymphocytes were assessed, together with their ratio, in 17 subjects who had received thymopentine as an adjuvant to Hevac-B vaccination. Two months after treatment with the immunomodulating drug, T4 lymphocytes were considerably increased whereas absolute levels of T8 lymphocytes were decreased in the majority of patients: this led to a net increase in the T4/T8 ratio. This finding leads to the conclusion that all subjects produced anti-HBs antibodies as a means of protection.
对17名接受胸腺五肽作为乙肝疫苗（Hevac - B）接种佐剂的受试者的辅助性T细胞（T4）和抑制性T细胞（T8）水平及其比例进行了评估。在使用免疫调节药物治疗两个月后，大多数患者的T4淋巴细胞显著增加，而T8淋巴细胞的绝对水平下降：这导致T4/T8比值净增加。这一发现得出结论，所有受试者均产生了抗乙肝表面抗原抗体作为一种保护手段。
