Department of Cardiothoracic Surgery, University Medical Center Utrecht, PO BOX 85500, E03.511, 3508GA, Utrecht, the Netherlands,
Neth Heart J. 2012 Jun;20(6):270-8. doi: 10.1007/s12471-011-0230-1.
Calcific aortic valve disease (CAVD) results in aortic valve stenosis and is one of the most common cardiac diseases in both Western and developing countries. The burden of this disease is expected to increase rapidly in the future, but there are still no relevant pharmacological therapies available and aortic valve replacement remains the sole definite therapy. This review presents an overview of the most common causes of CAVD, followed by current debates and trials related to the onset and progression of this disease. Several differences and similarities between the different causes of CAVD are presented. Additionally, stages of CAVD are compared with stages in atherosclerosis. Finally, future directions for research on CAVD will be discussed.
钙化性主动脉瓣疾病（CAVD）可导致主动脉瓣狭窄，是西方国家和发展中国家最常见的心脏疾病之一。预计未来这种疾病的负担将迅速增加，但目前仍没有相关的药物治疗方法，主动脉瓣置换仍然是唯一明确的治疗方法。本综述概述了 CAVD 的最常见病因，随后介绍了与这种疾病的发生和进展相关的当前争议和试验。介绍了 CAVD 不同病因之间的一些差异和相似之处。此外，还比较了 CAVD 分期与动脉粥样硬化分期。最后，将讨论 CAVD 研究的未来方向。
