急性经口给予 Wistar 大鼠氧化铝纳米材料后诱导的氧化应激。
Oxidative stress induced by aluminum oxide nanomaterials after acute oral treatment in Wistar rats.
机构信息
Toxicology Unit, Indian Institute of Chemical Technology, Hyderabad, Andhra Pradesh, India.
出版信息
J Appl Toxicol. 2012 Jun;32(6):436-45. doi: 10.1002/jat.1775. Epub 2011 Dec 7.
This study investigated the oxidative stress induced after acute oral treatment with 500, 1000 and 2000 mg kg⁻¹ doses of Al₂O₃ -30 and -40 nm and bulk Al₂O₃ in Wistar rats. Both the nanomaterials induced significant oxidative stress in a dose-dependent manner in comparison to the bulk. There was no significant difference between the two nanomaterials. However, the effect decreased with increase with time after treatment. The histopathological examination showed lesions only in liver with Al₂O₃ nanomaterials at 2000 mg kg⁻¹.
本研究调查了急性经口给予 500、1000 和 2000 mg kg⁻¹剂量的 Al₂O₃-30 和 -40nm 纳米材料和块状 Al₂O₃后诱导的氧化应激。与块状材料相比，这两种纳米材料均以剂量依赖的方式引起显著的氧化应激，且二者之间无显著差异。然而，这种效应随着处理后时间的延长而降低。组织病理学检查显示，仅在肝脏中发现病变，且病变出现在经口给予 2000 mg kg⁻¹ Al₂O₃纳米材料的大鼠中。
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