Abbasalipourkabir Roghayeh, Moradi Hemen, Zarei Sadegh, Asadi Soheila, Salehzadeh Aref, Ghafourikhosroshahi Abolfazl, Mortazavi Motahareh, Ziamajidi Nasrin
Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Food Chem Toxicol. 2015 Oct;84:154-60. doi: 10.1016/j.fct.2015.08.019. Epub 2015 Aug 24.
The purpose of this study was to investigate the effects of zinc oxide nanoparticles (nZnO) on adult male Wistar rats. Thirty male Wistar rats divided into five groups of six animals each were used for this study. For ten days, Groups one to four continuously received 50, 100, 150 and 200 mg/kg nZnO, respectively. Group five served as the control group. At the end of the study, the rats were sacrificed and histopathological study of the liver and renal tissue, sperm analysis, serum oxidative stress parameters and some liver enzymes were done. The results of this study showed that nZnO at concentration more than 50 mg/kg lead to significant changes in liver enzymes, oxidative stress, liver and renal tissue and sperm quality and quantity. In conclusion, the toxicity of nZnO is more significant when the concentration is increased; however, the use of low doses requires further investigation.
本研究的目的是调查氧化锌纳米颗粒（nZnO）对成年雄性Wistar大鼠的影响。本研究使用了30只雄性Wistar大鼠，将其分为五组，每组六只动物。连续十天，第一组至第四组分别持续接受50、100、150和200 mg/kg的nZnO。第五组作为对照组。在研究结束时，处死大鼠并对肝脏和肾脏组织进行组织病理学研究、进行精子分析、检测血清氧化应激参数和一些肝脏酶。本研究结果表明，浓度超过50 mg/kg的nZnO会导致肝脏酶、氧化应激、肝脏和肾脏组织以及精子质量和数量发生显著变化。总之，nZnO的毒性在浓度增加时更为显著；然而，低剂量使用需要进一步研究。
