从枸杞种子中分离得到的两个新甾体生物碱糖苷。

Two novel steroidal alkaloid glycosides from the seeds of Lycium barbarum.

机构信息

Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan.

出版信息

Chem Biodivers. 2011 Dec;8(12):2277-84. doi: 10.1002/cbdv.201000293.

DOI:10.1002/cbdv.201000293

Abstract

Two novel steroidal alkaloid glycosides, lycioside A (1) and lycioside B (2) were isolated from the seeds of Lycium barbarum. Their structures were determined by various spectroscopic analyses. Compounds 1 and 2 showed inhibitory activities with the IC(50) values of 75.3 and 72.8 μM against rat intestinal sucrase, and 63.4 and 59.1 μM against rat intestinal maltase.

摘要

从枸杞种子中分离得到了两个新甾体生物碱糖苷，lycioside A（1）和lycioside B（2）。通过各种光谱分析确定了它们的结构。化合物 1 和 2 对大鼠肠蔗糖酶的 IC50 值分别为 75.3 和 72.8 μM，对大鼠肠麦芽糖酶的 IC50 值分别为 63.4 和 59.1 μM，表现出抑制活性。