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The effects of HIV protease inhibitors atazanavir and lopinavir/ritonavir on insulin sensitivity in HIV-seronegative healthy adults.HIV蛋白酶抑制剂阿扎那韦和洛匹那韦/利托那韦对HIV血清学阴性健康成年人胰岛素敏感性的影响。
AIDS. 2004 Nov 5;18(16):2137-44. doi: 10.1097/00002030-200411050-00005.
2
Indinavir increases glucose production in healthy HIV-negative men.茚地那韦可增加健康的HIV阴性男性的葡萄糖生成。
AIDS. 2004 Sep 3;18(13):1852-4. doi: 10.1097/00002030-200409030-00017.
3
Comparison of once-daily atazanavir with efavirenz, each in combination with fixed-dose zidovudine and lamivudine, as initial therapy for patients infected with HIV.每日一次的阿扎那韦与依非韦伦分别联合固定剂量的齐多夫定和拉米夫定作为HIV感染患者初始治疗的比较。
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AIDS Res Hum Retroviruses. 2004 Jun;20(6):589-94. doi: 10.1089/0889222041217374.
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Direct interference of HIV protease inhibitors with pancreatic beta-cell function.HIV蛋白酶抑制剂对胰腺β细胞功能的直接干扰。
Naunyn Schmiedebergs Arch Pharmacol. 2004 Jun;369(6):583-90. doi: 10.1007/s00210-004-0933-6. Epub 2004 May 7.
6
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The metabolic effects of lopinavir/ritonavir in HIV-negative men.洛匹那韦/利托那韦对HIV阴性男性的代谢影响。
AIDS. 2004 Mar 5;18(4):641-9. doi: 10.1097/00002030-200403050-00008.
8
Safety, efficacy and development of resistance under the new protease inhibitor lopinavir/ritonavir: 48-week results.新型蛋白酶抑制剂洛匹那韦/利托那韦的安全性、疗效及耐药性演变：48周结果
Infection. 2004 Apr;32(2):82-8. doi: 10.1007/s15010-004-3059-3.
9
Risk of metabolic abnormalities in patients infected with HIV receiving antiretroviral therapy that contains lopinavir-ritonavir.接受含洛匹那韦-利托那韦的抗逆转录病毒治疗的HIV感染患者发生代谢异常的风险。
Clin Infect Dis. 2004 Apr 1;38(7):1017-23. doi: 10.1086/382531. Epub 2004 Mar 15.
10
Lopinavir/ritonavir vs. indinavir/ritonavir in antiretroviral naive HIV-infected patients: immunovirological outcome and side effects.洛匹那韦/利托那韦与茚地那韦/利托那韦用于初治HIV感染患者的抗逆转录病毒治疗：免疫病毒学结果及副作用
Antiviral Res. 2004 Apr;62(1):53-6. doi: 10.1016/j.antiviral.2003.12.002.

与蛋白酶抑制剂和非核苷类逆转录酶抑制剂使用相关的代谢异常

Metabolic Abnormalities Associated with the Use of Protease Inhibitors and Non-nucleoside Reverse Transcriptase Inhibitors.

作者信息

Rao Madhu N, Lee Grace A, Grunfeld Carl

机构信息

Department of Medicine, University of California at San Francisco.

出版信息

Am J Infect Dis. 2006 Sep 30;2(3):159-166. doi: 10.3844/ajidsp.2006.159.166.

DOI:10.3844/ajidsp.2006.159.166
PMID:22162956
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3233228/
Abstract

The use of protease inhibitors and non-nucleoside reverse transcriptase inhibitors for the treatment of HIV infection and AIDS has been associated with multiple abnormalities in glucose and lipid metabolism. Specifically, these abnormalities include insulin resistance, increased triglycerides and increased LDL cholesterol levels. The metabolic disturbances are due to a combination of factors, including the direct effect of medications, restoration to health and HIV disease, as well as individual genetic predisposition. Of the available anti-retroviral medications, indinavir has been associated with causing the most insulin resistance and ritonavir with causing the most hypertriglyceridemia.

摘要

使用蛋白酶抑制剂和非核苷类逆转录酶抑制剂治疗HIV感染和艾滋病与葡萄糖及脂质代谢的多种异常有关。具体而言，这些异常包括胰岛素抵抗、甘油三酯升高和低密度脂蛋白胆固醇水平升高。代谢紊乱是由多种因素共同导致的，包括药物的直接作用、健康恢复和HIV疾病，以及个体的遗传易感性。在现有的抗逆转录病毒药物中，茚地那韦与导致最多的胰岛素抵抗有关，利托那韦与导致最多的高甘油三酯血症有关。