Chen Xiuxu, Leach Daniel, Hunter Desiré A, Sanfelippo Daniel, Buell Erika J, Zemple Sarah J, Grayson Mitchell H
Division of Allergy and Clinical Immunology, Department of Pediatrics, Medical College of Wisconsin.
Open Immunol J. 2011;4:22-30. doi: 10.2174/1874226201104010022.
We have shown that respiratory viral infections drive allergic disease through dendritic cells, whether gastrointestinal viruses induce allergies is not known. Norovirus infections are a major cause of gastroenteritis in humans. We used murine norovirus (MNV) to explore the effect of MNV infection on gastrointestinal conventional DCs (cDCs) and plasmacytoid DCs (pDCs). MNV infection induced disparate effects on cDCs and pDCs in lymphoid tissues of the small intestine and draining mesenteric lymph nodes. FcεRI was transiently expressed on lamina propria cDCs, but not on pDCs. In addition, feeding ovalbumin during the viral infection led to a modest, brief induction of anti-ovalbumin IgE. Together, these data suggest that like with a respiratory viral infection, an intestinal viral infection may be sufficient to induce changes in DCs and the generation of food-specific IgE. Whether this represents a novel mechanism of food allergy remains to be determined.
我们已经表明，呼吸道病毒感染通过树突状细胞引发过敏性疾病，而胃肠道病毒是否会诱发过敏尚不清楚。诺如病毒感染是人类肠胃炎的主要病因。我们使用鼠诺如病毒（MNV）来探究MNV感染对胃肠道常规树突状细胞（cDCs）和浆细胞样树突状细胞（pDCs）的影响。MNV感染对小肠淋巴组织和引流肠系膜淋巴结中的cDCs和pDCs产生了不同的影响。FcεRI在固有层cDCs上短暂表达，但在pDCs上不表达。此外，在病毒感染期间喂食卵清蛋白会导致抗卵清蛋白IgE适度、短暂的诱导。总之，这些数据表明，与呼吸道病毒感染一样，肠道病毒感染可能足以诱导树突状细胞发生变化并产生食物特异性IgE。这是否代表食物过敏的一种新机制还有待确定。
