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用于神经元记录的 3D 微纳电极的制作与特性研究。

Fabrication and characterization of 3D micro- and nanoelectrodes for neuron recordings.

机构信息

Department of Micro- and Nanotechnology, Technical University of Denmark, DTU Nanotech, Building 345E, Kgs Lyngby, Denmark.

出版信息

Sensors (Basel). 2010;10(11):10339-55. doi: 10.3390/s101110339. Epub 2010 Nov 17.

DOI:10.3390/s101110339
PMID:22163473
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3231021/
Abstract

In this paper we discuss the fabrication and characterization of three dimensional (3D) micro- and nanoelectrodes with the goal of using them for extra- and intracellular studies. Two different types of electrodes will be described: high aspect ratio microelectrodes for studying the communication between cells and ultimately for brain slice recordings and small nanoelectrodes for highly localized measurements and ultimately for intracellular studies. Electrical and electrochemical characterization of these electrodes as well as the results of PC12 cell differentiation on chip will be presented and discussed.

摘要

在本文中，我们讨论了三维（3D）微纳电极的制作和特性，旨在将其用于细胞外和细胞内研究。将描述两种不同类型的电极：高纵横比微电极，用于研究细胞间的通讯，最终用于脑片记录；小纳米电极，用于高度局部化的测量，最终用于细胞内研究。将介绍和讨论这些电极的电学和电化学特性以及在芯片上进行 PC12 细胞分化的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ec/3231021/c0c46dcc4972/sensors-10-10339f12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ec/3231021/07859ca62515/sensors-10-10339f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ec/3231021/e8f6c4fa2f82/sensors-10-10339f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ec/3231021/a4e5bb751503/sensors-10-10339f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ec/3231021/ff62c1c1c055/sensors-10-10339f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ec/3231021/4563c5ad56b8/sensors-10-10339f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ec/3231021/b8ceea5ec4b8/sensors-10-10339f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ec/3231021/d8923bc91063/sensors-10-10339f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ec/3231021/341b9f2be4f5/sensors-10-10339f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ec/3231021/cc142a13b39f/sensors-10-10339f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ec/3231021/bbf253b7270b/sensors-10-10339f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ec/3231021/2a8751c18805/sensors-10-10339f11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ec/3231021/c0c46dcc4972/sensors-10-10339f12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ec/3231021/07859ca62515/sensors-10-10339f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ec/3231021/e8f6c4fa2f82/sensors-10-10339f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ec/3231021/a4e5bb751503/sensors-10-10339f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ec/3231021/ff62c1c1c055/sensors-10-10339f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ec/3231021/4563c5ad56b8/sensors-10-10339f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ec/3231021/b8ceea5ec4b8/sensors-10-10339f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ec/3231021/d8923bc91063/sensors-10-10339f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ec/3231021/341b9f2be4f5/sensors-10-10339f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ec/3231021/cc142a13b39f/sensors-10-10339f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ec/3231021/bbf253b7270b/sensors-10-10339f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ec/3231021/2a8751c18805/sensors-10-10339f11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ec/3231021/c0c46dcc4972/sensors-10-10339f12.jpg

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