Bao Zi-Ping, Cao Chun-Li, Dai Jian-Rong, Liu Jian-Bing, Li Guang-Ping, Guo Jian-Duo, Guo Jia-Gang
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Center for Malaria, Schistosomiasis and Filariasis, Shanghai 200025, China.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2011 Feb;23(1):48-53.
To evaluate the molluscicidal effect of suspension concentrate of 26% metaldehyde and niclosamide (MNSC) in laboratory and field.
The experiment of MNSC against Oncomelania snails were performed by immersion and spray methods with different time in laboratory and field, and the wettable powder of 50% niclosamide ethanolamine salt (WPN) and fresh water were set as the controls.
In laboratory, by immersion method (immersion for 24 h), LC50 of MNSC was 0.058 3 mg/L, which was lower than 0.094 7 mg/L of WPN. For the concentrations of 2.0 mg/L and 1.0 mg/L of MNSC by immersion method (immersion for 24, 48 h and 72 h, respectively), the death rates of snails were all 100%. In laboratory, by the spray method, the snail death rates were higher than 97% on the 3rd and 7th day when the dosage of MNSC was higher than 1.0 g/m2. In the field, by the immersion method, the snail death rates of MNSC (2 g/m3) for 24, 48 h and 72 h were 97.78% -100% in Hubei Province and 97.50% - 100% in Anhui Province, respectively, the rates of WPN were 98.89% - 100% and 97.56% - 100%, respectively, and the snail death rates of MNSC and WPN were both 100% in Jiangsu Province. In the field, by the spray method, the snail death rates of MNSC for 1, 3 d and 7 d were 83.12% - 94.64% in Jiangsu Province, 67.81% - 86.67% in Hubei Province and 72.80% - 100% in Anhui Province, respectively. The snail death rates of WPN for 1, 3 d and 7 d were 78.40% - 86.11%, 77.27% - 87.50% and 83.81% - 98.51%, respectively. In Hunan Province, the snail death rates of MNSC and WPN after spraying for 7 d were 94.94% and 94.20%, respectively, after spraying for 15 d, the rates were 86.67% and 89.38%, respectively.
The molluscicidal effect of MNSC is as the same as WPN by immersion and spray methods in laboratory and field. MNSC has the characteristics of good water solubility, quick dispersing and easy using. In addition, the efficiency component of MNSC is half of WPN. So MNSC is a novel form of molluscicide which is worthy of promotion in field.
评价26% 聚乙醛和氯硝柳胺悬浮剂（MNSC）在实验室及现场的杀螺效果。
采用浸泡法和喷洒法，在不同时间对MNSC进行实验室及现场杀螺实验，以50%氯硝柳胺乙醇胺盐可湿性粉剂（WPN）和清水作为对照。
在实验室，浸泡法（浸泡24 h）时，MNSC的LC50为0.058 3 mg/L，低于WPN的0.094 7 mg/L。浸泡法下，MNSC浓度为2.0 mg/L和1.0 mg/L（分别浸泡24、48 h和72 h）时，钉螺死亡率均为100%。在实验室，喷洒法下，当MNSC剂量高于1.0 g/m²时，第3天和第7天钉螺死亡率高于97%。在现场，浸泡法下，湖北省MNSC（2 g/m³）浸泡24、48 h和72 h的钉螺死亡率分别为97.78% - 100%，安徽省为97.50% - 100%；WPN的死亡率分别为98.89% - 100%和97.56% - 100%；江苏省MNSC和WPN的钉螺死亡率均为100%。在现场，喷洒法下，江苏省MNSC处理1、3 d和7 d的钉螺死亡率分别为83.1
