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哮喘。

Asthma.

机构信息

University of Western Ontario, London, Ontario, Canada.

出版信息

Allergy Asthma Clin Immunol. 2011 Nov 10;7 Suppl 1(Suppl 1):S2. doi: 10.1186/1710-1492-7-S1-S2.

DOI:10.1186/1710-1492-7-S1-S2
PMID:22165976
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3245435/
Abstract

Asthma is the most common respiratory disorder in Canada. Despite significant improvement in the diagnosis and management of this disorder, the majority of Canadians with asthma remain poorly controlled. In most patients, however, control can be achieved through the use of avoidance measures and appropriate pharmacological interventions. Inhaled corticosteroids (ICSs) represent the standard of care for the majority of patients. Combination ICS/long-acting beta2-agonists (LABA) inhalers are preferred for most adults who fail to achieve control with ICS therapy. Allergen-specific immunotherapy represents a potentially disease-modifying therapy for many patients with asthma, but should only be prescribed by physicians with appropriate training in allergy. Regular monitoring of asthma control, adherence to therapy and inhaler technique are also essential components of asthma management. This article provides a review of current literature and guidelines for the appropriate diagnosis and management of asthma.

摘要

哮喘是加拿大最常见的呼吸道疾病。尽管在该疾病的诊断和管理方面取得了重大进展,但大多数哮喘患者的病情仍未得到良好控制。然而,在大多数患者中,通过使用避免措施和适当的药物干预可以实现控制。吸入皮质类固醇(ICS)是大多数患者的标准治疗方法。对于大多数未能通过 ICS 治疗控制病情的患者,首选联合 ICS/长效β2-激动剂(LABA)吸入器。过敏原特异性免疫疗法是许多哮喘患者潜在的疾病修正治疗方法,但只能由经过适当过敏培训的医生开具处方。定期监测哮喘控制情况、坚持治疗和吸入器技术也是哮喘管理的重要组成部分。本文综述了当前关于哮喘的诊断和管理的文献和指南。

相似文献

1
Asthma.哮喘。
Allergy Asthma Clin Immunol. 2011 Nov 10;7 Suppl 1(Suppl 1):S2. doi: 10.1186/1710-1492-7-S1-S2.
2
Asthma.哮喘
Allergy Asthma Clin Immunol. 2018 Sep 12;14(Suppl 2):50. doi: 10.1186/s13223-018-0279-0. eCollection 2018.
3
Systematic review and economic analysis of the comparative effectiveness of different inhaled corticosteroids and their usage with long-acting beta2 agonists for the treatment of chronic asthma in adults and children aged 12 years and over.不同吸入性糖皮质激素及其与长效β2受体激动剂联合使用治疗12岁及以上成人和儿童慢性哮喘比较效果的系统评价与经济学分析
Health Technol Assess. 2008 May;12(19):iii-iv, 1-360. doi: 10.3310/hta12190.
4
Systematic review and economic analysis of the comparative effectiveness of different inhaled corticosteroids and their usage with long-acting beta2 agonists for the treatment of chronic asthma in children under the age of 12 years.不同吸入性糖皮质激素及其与长效β2受体激动剂联合使用治疗12岁以下儿童慢性哮喘的比较效果的系统评价和经济学分析
Health Technol Assess. 2008 May;12(20):1-174, iii-iv. doi: 10.3310/hta12200.
5
Long-acting beta2-agonists versus anti-leukotrienes as add-on therapy to inhaled corticosteroids for chronic asthma.长效β2受体激动剂与抗白三烯药物作为吸入性糖皮质激素治疗慢性哮喘的附加疗法比较
Cochrane Database Syst Rev. 2005 Jan 25(1):CD003137. doi: 10.1002/14651858.CD003137.pub2.
6
Addition to inhaled corticosteroids of long-acting beta2-agonists versus anti-leukotrienes for chronic asthma.长效β2受体激动剂与抗白三烯药物联合吸入糖皮质激素治疗慢性哮喘的比较
Cochrane Database Syst Rev. 2011 May 11(5):CD003137. doi: 10.1002/14651858.CD003137.pub4.
7
Addition of inhaled long-acting beta2-agonists to inhaled steroids as first line therapy for persistent asthma in steroid-naive adults.在未使用过类固醇的成年持续性哮喘患者中,吸入长效β2受体激动剂联合吸入性类固醇作为一线治疗方案。
Cochrane Database Syst Rev. 2005 Apr 18(2):CD005307. doi: 10.1002/14651858.CD005307.
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Long-acting beta2-agonists versus anti-leukotrienes as add-on therapy to inhaled corticosteroids for chronic asthma.长效β2受体激动剂与抗白三烯药物作为吸入性糖皮质激素治疗慢性哮喘的附加疗法比较
Cochrane Database Syst Rev. 2006 Oct 18(4):CD003137. doi: 10.1002/14651858.CD003137.pub3.
9
Combination of inhaled long-acting beta2-agonists and inhaled steroids versus higher dose of inhaled steroids in children and adults with persistent asthma.吸入长效β2受体激动剂与吸入性糖皮质激素联合使用与高剂量吸入性糖皮质激素治疗儿童和成人持续性哮喘的比较
Cochrane Database Syst Rev. 2005 Oct 19(4):CD005533. doi: 10.1002/14651858.CD005533.
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Physicians' attitudes towards combination therapy with inhaled corticosteroids and long-acting β-agonists: an observational study in UK specialist care.医生对吸入性糖皮质激素与长效β受体激动剂联合治疗的态度:英国专科护理的一项观察性研究。
Pragmat Obs Res. 2011 Dec 15;2:25-31. doi: 10.2147/POR.S24674. eCollection 2011.

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Sensors (Basel). 2024 Nov 23;24(23):7476. doi: 10.3390/s24237476.
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Acquisition and Classification of Lung Sounds for Improving the Efficacy of Auscultation Diagnosis of Pulmonary Diseases.用于提高肺部疾病听诊诊断效能的肺音采集与分类
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Update on the role of endoplasmic reticulum stress in asthma.

本文引用的文献

1
Steroid-sparing effects with allergen-specific immunotherapy in children with asthma: a randomized controlled trial.哮喘患儿中过敏原特异性免疫治疗的类固醇节省效应:一项随机对照试验。
J Allergy Clin Immunol. 2010 Nov;126(5):942-9. doi: 10.1016/j.jaci.2010.06.002. Epub 2010 Jul 10.
2
Canadian Thoracic Society Asthma Management Continuum--2010 Consensus Summary for children six years of age and over, and adults.加拿大胸科协会哮喘管理连续性--2010 年共识总结,适用于 6 岁及以上儿童和成人。
Can Respir J. 2010 Jan-Feb;17(1):15-24. doi: 10.1155/2010/827281.
3
Asthma: clinical expression and molecular mechanisms.
内质网应激在哮喘中作用的最新进展
Am J Transl Res. 2020 Apr 15;12(4):1168-1183. eCollection 2020.
4
Language of written medical educational materials for non-English speaking populations: an evaluation of a simplified bi-lingual approach.面向非英语人群的医学教育材料的书面语言:简化双语方法的评估。
BMC Med Educ. 2019 Nov 11;19(1):418. doi: 10.1186/s12909-019-1846-x.
5
Quantum dots and mouse strain influence house dust mite-induced allergic airway disease.量子点和小鼠品系影响屋尘螨诱导的过敏性气道疾病。
Toxicol Appl Pharmacol. 2019 Apr 1;368:55-62. doi: 10.1016/j.taap.2019.01.018. Epub 2019 Jan 23.
6
Understanding the Unfolded Protein Response in the Pathogenesis of Asthma.了解 unfolded protein response 在哮喘发病机制中的作用。
Front Immunol. 2018 Feb 6;9:175. doi: 10.3389/fimmu.2018.00175. eCollection 2018.
7
Asthma control among adults in Saudi Arabia. Study of determinants.沙特阿拉伯成年人的哮喘控制情况。决定因素研究。
Saudi Med J. 2015 May;36(5):599-604. doi: 10.15537/smj.2015.5.10929.
8
CSACI position statement: systemic effect of inhaled corticosteroids on adrenal suppression in the management of pediatric asthma.CSACI 立场声明:吸入皮质类固醇对儿童哮喘管理中肾上腺抑制的全身作用。
Allergy Asthma Clin Immunol. 2015 Mar 14;11(1):9. doi: 10.1186/s13223-015-0075-z. eCollection 2015.
9
Empowering pharmacists in asthma management through interactive SMS (EmPhAsIS): study protocol for a randomized controlled trial.通过交互式短信增强药剂师在哮喘管理中的作用(EmPhAsIS):一项随机对照试验的研究方案
Trials. 2014 Dec 13;15:488. doi: 10.1186/1745-6215-15-488.
10
Improving asthma management: the case for mandatory inclusion of dose counters on all rescue bronchodilators.改善哮喘管理:关于强制要求在所有急救支气管扩张剂上配备剂量计数器的理由。
J Asthma. 2013 Aug;50(6):658-63. doi: 10.3109/02770903.2013.789056. Epub 2013 Apr 29.
哮喘:临床表型与分子机制。
J Allergy Clin Immunol. 2010 Feb;125(2 Suppl 2):S95-102. doi: 10.1016/j.jaci.2009.10.047.
4
Allergen immunotherapy.变应原免疫治疗。
J Allergy Clin Immunol. 2010 Feb;125(2 Suppl 2):S306-13. doi: 10.1016/j.jaci.2009.10.064.
5
Achieving control of asthma in preschoolers.实现学龄前儿童哮喘的控制。
CMAJ. 2010 Mar 9;182(4):E172-83. doi: 10.1503/cmaj.071638. Epub 2009 Nov 23.
6
Upper airway x 1: allergic rhinitis and asthma: united disease through epithelial cells.上呼吸道 x1:过敏性鼻炎和哮喘:通过上皮细胞发生的联合疾病。
Thorax. 2009 Nov;64(11):999-1004. doi: 10.1136/thx.2008.112862.
7
Diagnosis of asthma in adults.成人哮喘的诊断
CMAJ. 2009 Nov 10;181(10):E210-20. doi: 10.1503/cmaj.080006. Epub 2009 Sep 21.
8
Efficacy of sublingual immunotherapy in asthma: systematic review of randomized-clinical trials using the Cochrane Collaboration method.
Allergy. 2006 Oct;61(10):1162-72. doi: 10.1111/j.1398-9995.2006.01205.x.
9
Asthma control in Canada remains suboptimal: the Reality of Asthma Control (TRAC) study.加拿大的哮喘控制情况仍未达到最佳水平:哮喘控制现状(TRAC)研究。
Can Respir J. 2006 Jul-Aug;13(5):253-9. doi: 10.1155/2006/753083.
10
Summary of recommendations from the Canadian Asthma Consensus guidelines, 2003.《2003年加拿大哮喘共识指南》推荐意见摘要
CMAJ. 2005 Sep 13;173(6 Suppl):S3-11.