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用于骨修复的含45S5生物玻璃的硫酸钙支架的稳定性增强

Enhanced Stability of Calcium Sulfate Scaffolds with 45S5 Bioglass for Bone Repair.

作者信息

Shuai Cijun, Zhou Jianhua, Wu Ping, Gao Chengde, Feng Pei, Xiao Tao, Deng Youwen, Peng Shuping

机构信息

State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China.

College of Chemistry, Xiangtan University, Xiangtan 411105, China.

出版信息

Materials (Basel). 2015 Nov 6;8(11):7498-7510. doi: 10.3390/ma8115398.

DOI:10.3390/ma8115398
PMID:28793652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5458930/
Abstract

Calcium sulfate (CaSO₄), as a promising tissue repair material, has been applied widely due to its outstanding bioabsorbability and osteoconduction. However, fast disintegration, insufficient mechanical strength and poor bioactivity have limited its further application. In the study, CaSO₄ scaffolds fabricated by using selective laser sintering were improved by adding 45S5 bioglass. The 45S5 bioglass enhanced stability significantly due to the bond effect of glassy phase between the CaSO₄ grains. After immersing for four days in simulated body fluid (SBF), the specimens with 45S5 bioglass could still retain its original shape compared as opposed to specimens without 45S5 bioglass who experienced disintegration. Meanwhile, its compressive strength and fracture toughness increased by 80% and 37%, respectively. Furthermore, the apatite layer was formed on the CaSO₄ scaffolds with 45S5 bioglass in SBF, indicating good bioactivity of the scaffolds. In addition, the scaffolds showed good ability to support the osteoblast-like cell adhesion and proliferation.

摘要

硫酸钙（CaSO₄）作为一种很有前景的组织修复材料，因其出色的生物可吸收性和骨传导性而被广泛应用。然而，快速分解、机械强度不足和生物活性差限制了其进一步应用。在本研究中，通过添加45S5生物玻璃对采用选择性激光烧结制备的硫酸钙支架进行了改进。由于CaSO₄颗粒之间玻璃相的粘结作用，45S5生物玻璃显著提高了稳定性。在模拟体液（SBF）中浸泡四天后，与未添加45S5生物玻璃而发生分解的试样相比，添加了45S5生物玻璃的试样仍能保持其原始形状。同时，其抗压强度和断裂韧性分别提高了80%和37%。此外，在含有45S5生物玻璃的CaSO₄支架上于SBF中形成了磷灰石层，表明该支架具有良好的生物活性。此外，该支架表现出良好的支持成骨样细胞粘附和增殖的能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9440/5458930/7bd9c7c10a64/materials-08-05398-g013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9440/5458930/7bd9c7c10a64/materials-08-05398-g013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9440/5458930/5c105c258f78/materials-08-05398-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9440/5458930/fb80982fcfb9/materials-08-05398-g010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9440/5458930/7bd9c7c10a64/materials-08-05398-g013.jpg

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