INRA, UMR1260 and INSERM ERL1025 "Nutriments Lipidiques et Prévention des Maladies Métaboliques", Faculté de Médecine, IPHM-IFR 125, 27 Boulevard Jean Moulin, Marseille, 13385 Cedex 05, France.
Public Health Nutr. 2011 Dec;14(12A):2302-8. doi: 10.1017/S1368980011002552.
To determine the postprandial lipaemia response before and after intervention with healthy diets in the Medi-RIVAGE cohort of subjects with moderate risk factors of CVD.
One hundred and thirty-five adults (fifty-two men and eighty-three women) followed either a Mediterranean-type (MED) diet or a low-fat American Heart Association-type diet in a parallel design for 3 months. At entry and after 3 months, lipids, glucose and insulin were measured in the fasting samples; TAG and apolipoprotein B48 (ApoB48; a marker of intestinally derived chylomicrons) levels were measured in the fasting and postprandial samples after a standard test meal.
The MED diet only lowered (P < 0·028) fasting TAG and both diets reduced TAG and ApoB48 levels 5 h after the test meal. The overall 5 h postprandial ApoB48 response (area under curve (AUC)/incremental AUC) was lowered after both diets but this effect was more marked after the MED-diet intervention. Whatever the TAG level at entry, normo- and hyper TAG subjects showed a reduction in the postprandial ApoB48 levels after 3-month diets. BMI at entry did not impact the effect of diets given subjects with BMI < or >25 kg/m2 showed reduced postprandial ApoB48. Men and women displayed comparable postprandial changes after dietary challenges.
A MED diet appears efficient to improve postprandial lipaemia, a recently acknowledged CVD risk, in men and women at moderate cardiovascular risk.
在心血管疾病中度危险因素的 Medi-RIVAGE 队列中，通过健康饮食干预前后，确定餐后血脂反应。
135 名成年人（52 名男性和 83 名女性）以平行设计的方式分别遵循地中海饮食或低脂美国心脏协会饮食 3 个月。在入组时和 3 个月后，空腹样本中测量了血脂、血糖和胰岛素；在空腹和标准测试餐后 5 小时测量了 TAG 和载脂蛋白 B48（apoB48；肠源性乳糜微粒的标志物）水平。
地中海饮食仅降低（P<0·028）空腹 TAG，两种饮食均降低了餐后 5 小时的 TAG 和 apoB48 水平。两种饮食后，总体 5 小时餐后 apoB48 反应（曲线下面积（AUC）/增量 AUC）降低，但地中海饮食干预后效果更为明显。无论入组时的 TAG 水平如何，正常和高 TAG 受试者在 3 个月的饮食后，餐后 apoB48 水平均降低。入组时的 BMI 不影响饮食的影响，BMI<或>25 kg/m2 的受试者显示餐后 apoB48 降低。男性和女性在饮食挑战后显示出类似的餐后变化。
地中海饮食似乎能够有效改善男性和女性心血管疾病中度风险人群的餐后血脂血症，这是最近被认可的心血管疾病风险。
