Institute of Epidemiology I, German Research Center for Environmental Health (GmbH), Helmholtz Zentrum München, Neuherberg, Germany.
Obes Facts. 2011;4(5):379-85. doi: 10.1159/000333428. Epub 2011 Oct 14.
We analyzed the magnitude of the association between cardiovascular disease (CVD) risk factors and various measures of overweight among adolescents, to determine which indicator of overweight is most relevant for risk assessment.
5,546 boys and girls aged 11-17 years participating in the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) were studied. Overweight was assumed when different anthropometric variables exceeded age- and sex-specific 90th percentiles. Blood pressure was measured and blood samples were analyzed for serum total cholesterol, lipoproteins, high-sensitivity C-reactive protein, and glycosylated hemoglobin (HbA1c).
In both sexes, overweight was significantly associated with adverse levels of CVD risk factors, except HbA1c. These associations were most pronounced for overweight as defined by waist circumference (WC), waist-to-height ratio (WHtR), or BMI. Between 11% and 37% of the overweight children exceeded the defined cut-offs for individual CVD risk factors, with age- and puberty-adjusted significant odds ratios (95% confidence interval (CI)) in comparison to normal-weight age mates ranging from 1.7 (1.0-3.0) to 6.1 (4.5-8.2).
The findings of this population-based survey suggest that, among adolescents, WC, WHtR, and BMI are easily applicable measures of overweight that appear to be relevant for CVD risk assessment.
我们分析了心血管疾病（CVD）危险因素与青少年超重的各种指标之间的关联程度，以确定超重的哪个指标与风险评估最相关。
研究了参加德国儿童和青少年健康访谈和体检调查（KiGGS）的 5546 名 11-17 岁的男孩和女孩。当不同的人体测量变量超过年龄和性别特定的第 90 百分位时，就认为超重。测量血压并分析血清总胆固醇、脂蛋白、高敏 C 反应蛋白和糖化血红蛋白（HbA1c）。
在男性和女性中，超重与 CVD 危险因素的不良水平显著相关，除了 HbA1c。这些关联在腰围（WC）、腰高比（WHtR）或 BMI 定义的超重中最为明显。在超重的儿童中，有 11%至 37%超过了个体 CVD 危险因素的定义截止值，与正常体重的同龄儿童相比，经过年龄和青春期调整的显著比值比（95%置信区间（CI））范围从 1.7（1.0-3.0）到 6.1（4.5-8.2）。
这项基于人群的调查结果表明，在青少年中，WC、WHtR 和 BMI 是适用于超重的简单指标，似乎与 CVD 风险评估相关。
