Plhalova Lucie, Haluzova Ivana, Macova Stanislava, Dolezelova Petra, Praskova Eva, Marsalek Petr, Skoric Misa, Svobodova Zdenka, Pistekova Vladimira, Bedanova Iveta
Department of Veterinary Public Health and Toxicology, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.
Neuro Endocrinol Lett. 2011;32 Suppl 1:89-94.
Simazine is a triazine herbicide which has been used for a long period in agriculture and in the aquatic environment for control of weeds and algae. The aim of this study was to investigate the effects of subchronic exposure to simazine on growth and the development of histopathological changes in selected organs (gills, kidney, liver) in Danio rerio.
Juvenile growth tests were performed on D. rerio according to the OECD method No. 215. Fish at the age of 20 days were exposed to the environmental simazine concentration commonly detected in Czech rivers (0.06 μg.L-1) and a range of sublethal concentrations of simazine (0.6, 6.0 and 60.0 μg.L-1) for 28 days.
There were no significant differences (p<0.05) between the specific growth rates (r) of the test groups and those of both control groups. Histopathological examination revealed pathological changes in fish exposed to a simazine concentration of 60.0 μg.L-1. The values of NOEC and LOEC of simazine were 6.0 μg.L-1 and 60.0 μg.L-1.
The environmental concentration of simazine in Czech rivers did not have any effects on the growth and development of histopathological changes in D. rerio.
西玛津是一种三嗪类除草剂，长期用于农业和水环境中以控制杂草和藻类。本研究的目的是调查亚慢性暴露于西玛津对斑马鱼特定器官（鳃、肾脏、肝脏）生长和组织病理学变化发展的影响。
根据经合组织第215号方法对斑马鱼进行幼鱼生长试验。将20日龄的鱼暴露于捷克河流中常见的环境西玛津浓度（0.06μg.L-1）以及一系列亚致死浓度的西玛津（0.6、6.0和60.0μg.L-1）中28天。
试验组的特定生长率（r）与两个对照组之间无显著差异（p<0.05）。组织病理学检查显示，暴露于60.0μg.L-西玛津浓度的鱼出现了病理变化。西玛津的无观察效应浓度（NOEC）和最低观察效应浓度（LOEC）分别为6.0μg.L-1和60.0μg.L-1。
捷克河流中西玛津的环境浓度对斑马鱼的生长和组织病理学变化发展没有任何影响。
