中度或深度局部低温并不能预防缺血诱导的树突损伤的发生。
Moderate or deep local hypothermia does not prevent the onset of ischemia-induced dendritic damage.
机构信息
Department of Psychiatry, Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia, Canada.
出版信息
J Cereb Blood Flow Metab. 2012 Mar;32(3):437-42. doi: 10.1038/jcbfm.2011.178. Epub 2011 Dec 14.
Abstract
We studied the acute (up to 2 hours after reperfusion) effects of localized cortical hypothermia on ischemia-induced dendritic structural damage. Moderate (31°C) and deep (22°C) hypothermia delays, but does not block the onset of dendritic blebbing or spine loss during global ischemia in mouse in vivo. Hypothermic treatment promoted more consistent recovery of dendritic structure and spines during reperfusion. These results suggest that those using therapeutic hypothermia will need to consider that it does not spare neurons from structural changes that are the result of ischemia, but hypothermia may interact with mechanisms that control the onset of damage and recovery during reperfusion.
摘要
我们研究了局部皮质低温对缺血诱导的树突状结构损伤的急性（再灌注后 2 小时内）影响。在体内，中度（31°C）和深度（22°C）低温可延迟，但不能阻止全脑缺血时树突起泡或棘突丢失的发生。低温治疗在再灌注期间促进了树突结构和棘突更一致的恢复。这些结果表明，使用治疗性低温的人将需要考虑到它不能使神经元免受缺血引起的结构变化的影响，但低温可能与控制再灌注期间损伤和恢复的机制相互作用。
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