Maszczyk Z, Radwan L, Koziorowski A
Zakładu Fizjopatologii Instytutu Gruźlicy, Chorób Płuc, Kierownik.
Pneumonol Pol. 1990 Jun;58(6):289-97.
22 normal volunteers, 57 patients with obstructive changes and 34 with restrictive type changes were studied. The following parameters were analyzed: maximal inspiratory and expiratory pressures, occlusion pressure and components of the breathing pattern. The patients were divided according to the degree of airway resistance and fall of vital capacity. All patients compared with the healthy volunteers demonstrated higher minute ventilation, and a higher neuro-muscular respiratory drive as shown by the VT/Ti index and occlusion pressure. The breathing pattern did not correlate significantly with the different abnormalities of respiratory function in the studied groups. In the patients with obstructive changes a weak correlation was found between the occlusion pressure and airway resistance. In patients with restrictive type changes a weak correlation between occlusion pressure, static and specific compliance was found. The occlusion pressure was a more specific parameter characterizing respiratory drive compared with the VT/Ti index. Disturbances of pulmonary mechanics have a small but significant effect on respiratory control.
对22名正常志愿者、57名有阻塞性改变的患者和34名有限制性改变的患者进行了研究。分析了以下参数：最大吸气和呼气压力、闭塞压和呼吸模式的组成部分。根据气道阻力程度和肺活量下降情况对患者进行分组。与健康志愿者相比，所有患者的分钟通气量更高，并且如VT/Ti指数和闭塞压所示，神经肌肉呼吸驱动力更高。呼吸模式与研究组中呼吸功能的不同异常情况无显著相关性。在有阻塞性改变的患者中，发现闭塞压与气道阻力之间存在弱相关性。在有限制性改变的患者中，发现闭塞压与静态顺应性和比顺应性之间存在弱相关性。与VT/Ti指数相比，闭塞压是表征呼吸驱动力的更具特异性的参数。肺力学紊乱对呼吸控制有微小但显著的影响。
