Van Meerhaeghe A, Scano G, Sergysels R, Bran M, De Coster A
Bull Eur Physiopathol Respir. 1981 Jan-Feb;17(1):15-26.
Ventilation was analysed during a maximal and progressive exercise in 12 patients suffering from interstitial lung disease (ILD) and in 15 healthy subjects. "Rapid shallowing breathing" pattern was observed in patients with ILD. Both normals and patients showed a linear relationship between VE, VT/TI (mean inspiratory flow) and VCO2. The relationship between P0.1, the occlusion pressure at 0.1 S, and VCO2 exponential in both groups and significantly steeper in patients with ILD. P0.1/VE and P0.1/(VT/TI) ratios, indexes of thoracopulmonary impedance, and P0.1/VCO2 ratio, an index of respiratory drive per unit of CO2 output, were all inversely correlated in patients with VC% (vital capacity) and CLstat (static compliance). These results strongly suggest that in patients suffering from ILD the higher respiratory drive observed during exercise could be attributed to increased afferent reflexes originating from the lung and/or chest wall.
对12例间质性肺疾病（ILD）患者和15名健康受试者在最大量递增运动期间的通气情况进行了分析。ILD患者中观察到了“快速浅呼吸”模式。正常人和患者的每分钟静息通气量（VE）、潮气量/吸气时间（VT/TI，平均吸气流量）与二氧化碳排出量（VCO2）之间均呈线性关系。两组中0.1秒时的阻断压（P0.1）与VCO2呈指数关系，且ILD患者组的该关系显著更陡峭。在肺活量（VC%）和静态顺应性（CLstat）的患者中，胸肺阻抗指标P0.1/VE和P0.1/(VT/TI)比值以及每单位二氧化碳排出量的呼吸驱动指标P0.1/VCO2比值均呈负相关。这些结果强烈表明，ILD患者在运动期间观察到的较高呼吸驱动可能归因于源自肺和/或胸壁的传入反射增加。
