[一项源自口腔黏膜下纤维化的口腔鳞状细胞癌的回顾性研究]
[A retrospective study of oral squamous cell carcinomas originated from oral submucous fibrosis].
作者信息
Guo Feng, Jian Xin-chun, Zhou Shang-hui, Li Ning, Hu Yan-jia, Tang Zhan-gui
机构信息
Department of Oral and Maxillofacial Surgery, Central South University, Changsha, China.
出版信息
Zhonghua Kou Qiang Yi Xue Za Zhi. 2011 Aug;46(8):494-7.
OBJECTIVE
To investigate the clinical characteristics, pathological and biological behaviors of oral squamous cell carcinomas (OSCC) originated from oral submucous fibrosis (OSF).
METHODS
A total of 528 patients with OSCC treated at Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University from 2002 to 2010 were divided into two groups, OSCC originated from OSF and OSCC not originated from OSF. The clinical data regarding age, gender, location, pathological type, metastasis and recurrence rate of these patients were analyzed retrospectively.
RESULTS
The mean age of the group of OSCC originated from OSF (45.8 years) was younger than that of the group of OSCC not originated from OSF (55.9 years). The male female ratio of the group of OSCC originated from OSF (32.3:1) was higher than that of the group of OSCC not originated from OSF (2.3:1). The metastasis and recurrence rate of the group of OSCC originated from OSF (13.5%, 39.1%) was higher than that of the group of OSCC not originated from OSF (7.6%, 27.8%.).
CONCLUSIONS
OSCC originated from OSF occurs at younger age and more in male, and is clinically more invasive and metastatic.
目的
探讨源自口腔黏膜下纤维化（OSF）的口腔鳞状细胞癌（OSCC）的临床特征、病理及生物学行为。
方法
将2002年至2010年在中南大学湘雅医院口腔颌面外科治疗的528例OSCC患者分为两组，即源自OSF的OSCC组和非源自OSF的OSCC组。对这些患者的年龄、性别、部位、病理类型、转移及复发率等临床资料进行回顾性分析。
结果
源自OSF的OSCC组患者的平均年龄（45.8岁）低于非源自OSF的OSCC组（55.9岁）。源自OSF的OSCC组的男女比例（32.3:1）高于非源自OSF的OSCC组（2.3:1）。源自OSF的OSCC组的转移及复发率（13.5%，39.1%）高于非源自OSF的OSCC组（7.6%，27.8%）。
结论
源自OSF的OSCC发病年龄较轻，男性居多，且在临床上具有更强的侵袭性和转移性。
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